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Psychiatry research, Neuroimaging v.260, 2017년, pp.16 - 22   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Altered patterns of association between cortical thickness and subcortical volume in patients with first episode major depressive disorder: A structural MRI study

Zhao, Ke (Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China ); Liu, Haiyan (Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China ); Yan, Rui (Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China ); Hua, Lingling (Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China ); Chen, Yu (Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China ); Shi, Jiabo (Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China ); Yao, Zhijian (Department of Psychiatry, Affiliated Nanjing Brain Hospital of Nanjing Medical University, Nanjing 210029, China ); Lu, Qing (Research Center of Learning Science, Southeast University, Nanjing 210096, China );
  • 초록  

    Abstract Depressed individuals may exhibit changes in cortical thickness and subcortical volume. However, we know little about their associated connection patterns in the brain's neural circuits. This study explored correlations between overall cortical thickness and the volume of several subcortical structures in first episode major depressive disorder (MDD) patients. Thirty-six untreated individuals experiencing their first episode of MDD were compared with healthy controls ( n = 41). Their brains were imaged by T1-weighted MRI, allowing the measurement of cortical thickness and the volume of subcortical structures. We found that in MDD patients, the cortex was thinner in four of the measured regions (frontal, temporal, parietal and insula) and the volume of the putamen and amygdala tended to be smaller compared with controls. Furthermore, the ratio of the volume of the four measured subcortical structures (left pallidum, left putamen, left amygdala and right caudate) to cortical thickness (measured in 11 regions)was significantly larger in the MDD group compared with controls. These results show that there are different relationships between subcortical volume and cortical thickness inearly-stage MDD and control subjects. Highlights Cortical thickness and subcotical volume decreased in patient group. Cortical thickness was positively correlated with subcortical volume in patient group. Altered patterns may be related to the onset of depression.


  • 주제어

    Cortical thickness .   Subcortical .   Major depressive disorder .   Structural MRI.  

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