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Psychiatry research, Neuroimaging v.260, 2017년, pp.23 - 28   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Lateralization of intrinsic frontoparietal network connectivity and symptoms in schizophrenia

Son, Shuraku (Department of Psychiatry, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan ); Miyata, Jun (Department of Psychiatry, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan ); Mori, Yasuo (Department of Psychiatry, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan ); Isobe, Masanori (Department of Psychiatry, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan ); Urayama, Shin-ichi (Human Brain Research Center, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan ); Aso, Toshihiko (Human Brain Research Center, Graduate School of Medicine, Kyoto University, 54 Shogoin-Kawaharacho, Sakyo-ku, Kyoto 606-8507, Japan ); Fukuyama, Hidenao (Research and Educational Unit of Leaders for Integrated Medical System, Center for the Promotion of Interdisciplinary Education and Research, Kyoto University, Japan ); Murai, Toshiya (Department of Psychiatry, Graduate Schoo ); Takahashi, Hidehiko ( );
  • 초록  

    Abstract It has been frequently reported that schizophrenia patients have reduced functional lateralization in the areas related to language processing. Furthermore, there is evidence supporting that schizophrenia patients have disrupted functional connectivity in the bilateral frontoparietal networks (FPNs), of which the left is strongly associated with a cognition-language paradigm, using resting-state functional magnetic resonance imaging (rsfMRI). To examine the laterality of resting-state functional connectivity in schizophrenia, we investigated the bilateral FPNs. We investigated 41 schizophrenia and 35 healthy participants using independent component analysis for rsfMRI. We extracted mean connectivity values of both left and right FPNs and calculated their laterality index by (left - right)/(left + right). Subsequently, we investigated group differences of these values and the correlation between these values and symptoms. In schizophrenia, mean connectivity values of both left and right FPNs were significantly lower than in healthy controls, whereas their laterality indices were not significantly different. However, correlation analyses revealed that the laterality index was negatively correlated with positive symptoms, and that mean connectivity of left FPN was negatively correlated with depressive symptoms in schizophrenia. Our results suggest that language-related networks and their laterality might be one of the neural correlates of schizophrenia symptoms. Highlights Laterality of bilateral FPN connectivity was not different in schizophrenia. It was negatively correlated with positive symptoms in schizophrenia. Left one was negatively correlated with depressive symptoms in schizophrenia.


  • 주제어

    Independent component analysis .   Resting state fMRI .   Laterality .   Asymmetry .   Positive symptoms .   Depressive symptoms.  

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