본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Psychiatry research, Neuroimaging v.260, 2017년, pp.53 - 61   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Cerebral blood flow and its connectivity features of auditory verbal hallucinations in schizophrenia: A perfusion study

Cui, Long-Biao (Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China ); Chen, Gang (Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China ); Xu, Zi-Liang (School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China ); Liu, Lin (School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi, China ); Wang, Hua-Ning (Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China ); Guo, Li (Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China ); Liu, Wen-Ming (Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China ); Liu, Ting-Ting (Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China ); Qi, Shun (Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China ); Liu, Kang (Department of Radiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, Chi ); Qin, Wei ( ); Sun, Jin-Bo ( ); Xi, Yi-Bin ( ); Yin, Hong ( );
  • 초록  

    Abstract The goal of the study was to investigate cerebral blood flow (CBF) and its connectivity (an across-subject covariance measure) patterns of schizophrenia (SZ) patients with auditory verbal hallucinations (AVHs). A total of demographically matched 25 SZ patients with AVHs, 25 without AVHs, and 25 healthy controls (HCs) underwent resting state perfusion imaging using a pulsed arterial spin labeling sequence. CBF and its connectivity were analyzed and then CBF topological properties were calculated. AVHs patients exhibited decreased CBF in the bilateral superior and middle frontal gyri and postcentral gyri, and right supplementary motor area compared with SZ patients without AVHs. SZ patients without AVHs showed reduced CBF in the left middle frontal gyrus relative to HCs. Moreover, AVHs groups showed distinct connectivity pattern, an intermediate level between HCs and patients without AVHs in the global efficiency. Our study demonstrates aberrant CBF in the brain regions associated with inner speech monitoring and language processing in SZ patients with AVHs. The complex network measures showed by CBF-derived functional connectivity indicate dysconnectivity between different functional units within the network of AVHs in SZ. Our findings might shed light on the neural underpinnings behind AVHs in this devastating disease at the level of CBF and its connectivity. Highlights AVHs in SZ show dysfunction of the regions involving speech imagery, production, and monitoring. SZ patients with AVHs showed deficit communication within the brain network. CBF values help to discriminate SZ patients with AVHs from those without AVHs. CBF measure might be an effective indicator of AVHs vulnerability in SZ patients.


  • 주제어

    Schizophrenia .   Auditory verbal hallucinations .   Arterial spin labeling .   Cerebral blood flow .   Language processing.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기