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Psychiatry research, Neuroimaging v.260, 2017년, pp.70 - 75   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Vertex-wise examination of depressive symptom dimensions and brain volumes in older adults

McLaren, Molly E. (Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA ) ; Szymkowicz, Sarah M. (Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA ) ; O'Shea, Andrew (Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA ) ; Woods, Adam J. (Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA ) ; Anton, Stephen D. (Department of Aging & Geriartric Research, University of Florida, 2004 Mowry Rd, Gainesville, FL, USA ) ; Dotson, Vonetta M. (Department of Clinical and Health Psychology, University of Florida, PO Box 100165, Gainesville, FL 32610-0165, USA ) ;
  • 초록  

    Abstract Differences in brain volumes have commonly been reported in older adults with both subthreshold and major depression. Few studies have examined the association between specific symptom dimensions of depression and brain volumes. This study used vertex-wise analyses to examine the association between specific symptom dimensions of depression and brain volumes in older adults with subthreshold levels of depressive symptoms. Forty-three community-dwelling adults between the ages of 55 and 81 years underwent a structural Magnetic Resonance Imaging scan and completed the Center for Epidemiologic Studies Depression Scale (CES-D). Vertex-wise analyses were conducted using Freesurfer Imaging Suite to examine the relationship between CES-D subscale scores and gray matter volumes while controlling for sex, age, and education. We found distinct associations between depressed mood, somatic symptoms, and lack of positive affect subscales with regional volumes, including primarily positive relationships in temporal regions and a negative association with the lingual gyrus. The relationship between higher depressed mood subscale scores and larger volumes in the left inferior temporal lobe withstood Monte-Carlo correction for multiple comparisons. Results from this preliminary study highlight the importance of examining depression on a symptom dimension level and identify brain regions that may be important in larger studies of depression. Highlights Relationships between depressive symptom dimensions and brain volumes were examined. Distinct associations between volumes and different symptom dimensions were found. Depressive symptoms had both positive and negative associations with volumes. Results highlight the importance of separately examining depressive symptom clusters.


  • 주제어

    Depressive symptoms .   Symptom dimensions .   Aging .   Brain .   MRI .   Vertex-wise analysis.  

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