Design and characterizations of novel biodegradable Zn-Cu-Mg alloys for potential biodegradable implants
Abstract Zn-3Cu-xMg (x=0, 0.1, 0.5 and 1.0wt.%) alloys were developed as potential biodegradable metallic materials in this study. The mechanical properties, corrosion behavior and in vitro cytocompatibility of Zn-3Cu-xMg alloys were studied systematically to evaluate the feasibility as biodegradable implant materials. The secondary phase in as-cast and as-extruded Zn-3Cu alloy was CuZn 5 phase. Mg 2 Zn 11 phase newly formed and precipitated by Mg addition. The volume fraction of Mg 2 Zn 11 phase increased gradually with increasing Mg concentration. As a result, yield strength was improved from 213.7 to 426.7MPa and increased by 99.7% while elongation decreased from 47.1% to 0.9%. Besides, biocompatibility was improved apparently and in vitro corrosion rates increased from 11.4 to 43.2μmyear −1 , which is more suitable for clinic application. The present research indicated that the newly developed alloys could be promising candidates for biomedical use due to the proper mechanical properties, degradation rate and acceptable biocompatibility. Highlights Mg 2 Zn 11 phase newly forms and precipitates by adding Mg into Zn-Cu alloy. Yield strength increases by 99.7% with 1Mg addition, indicating obvious strengthening effect of Mg for Zn-3Cu alloy. Ranging from 11.4 to 43.2 μm year -1 , the degradation rates of Zn-3Cu-xMg alloys are more suitable for clinic application. The cytocompatibility of Zn-3Cu is enhanced apparently by Mg addition. Graphical abstract [DISPLAY OMISSION]
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