Low vitamin D does not predict statin associated muscle symptoms but is associated with transient increases in muscle damage and pain
Background and aims: Low vitamin D (VITD) may contribute to statin-associated muscle symptoms (SAMS). We examined the influence of baseline and change in VITD in patients with verified SAMS. Methods: SAMS was verified in 120 patients with prior statin muscle complaints using 8-week randomized, double-blind crossover trials of simvastatin (SIMVA) 20 mg/d and placebo. 25 (OH)vitamin D was measured at each phase of the trial. Results: Forty-three patients (35.8%) experienced muscle pain on SIMVA but not placebo, exhibiting confirmed SAMS. VITD (mean +/- standard deviation) prior to SIMVA treatment was not different between patients who did (31.7 +/- 12.1 ng/mL, n = 43) or did not (31.6 +/- 10.3 ng/mL, n = 77) develop SAMS and did not predict SAMS (p = 0.96). The change in VITD with SIMVA treatment was not different between patients with and without SAMS (0.3 +/- 5.9 vs. 0.2 +/- 8.3 ng/mL, respectively) and did not predict SAMS (p = 0.96). The proportion of patients classified as VITD deficient ( 2 = 1.45; p = 0.23), nor did the proportion of patients classified as VITD insufficient ( 2
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- DOI : http://dx.doi.org/10.1016/j.atherosclerosis.2016.11.011
- Elsevier : 저널> 권호 > 논문
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