Spectroscopic investigation, vibrational assignments, HOMO-LUMO, NBO, MEP analysis and molecular docking studies of oxoaporphine alkaloid liriodenine
Abstract A combined experimental and theoretical DFT study of the structural, vibrational and electronic properties of liriodenine is presented using B3LYP function with 6-311G (2d, p) basis set. The theoretical geometry optimization data were compared with the X-ray data for a similar structure in the associated literature, showing similar values. In addition, natural bond orbitals (NBOs), HOMO-LUMO energy gap, mapped molecular Electrostatic Potential (MEP) surface calculation, first and second order hyperpolarizabilities were also performed with the same calculation level. Theoretical UV spectrum agreed well with the measured experimental data, with transitions assigned. The molecular electrostatic potential map shows opposite potentials regions that forms hydrogen bonds that stabilize the dimeric form, which were confirmed by the close values related to the C O bond stretching between the dimeric form and the experimental IR spectra (1654cm −1 for the experimental, 1700cm −1 for the dimer form). Calculated HOMO/LUMO gaps shows the excitation energy for Liriodenine, justifying its stability and kinetics reaction. Molecular docking studies with Candida albicans dihydrofolate reductase (DHFR) and Candida albicans secreted aspartic protease (SAP) showed binding free energies values of −8.5 and −8.3kcal/mol, suggesting good affinity between the liriodenine and the target macromolecules. Highlights The comparison between theoretical and experimental IR spectra showed the formation of dimers. Molecular electrostatic potential surface has been calculated. The calculated energy gap reveals the molecular activity of the title compound. Molecular docking reveals good affinity between liriodenine and the target macromolecules. Graphical Abstract [DISPLAY OMISSION]
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