본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy v.174, 2017년, pp.349 - 362   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Spectral and molecular modeling investigations of supramolecular complexes of mefenamic acid and aceclofenac with α- and β-cyclodextrin

Siva, S. (Department of Chemistry, Annamalai University, Annamalainagar, Tamil Nadu 608 002, India ) ; Kothai Nayaki, S. (Chemistry Section, FEAT, Annamalai University, Annamalainagar, Tamil Nadu 608 002, India ) ; Rajendiran, N. (Department of Chemistry, Annamalai University, Annamalainagar, Tamil Nadu 608 002, India ) ;
  • 초록  

    Abstract Inclusion complexes of mefenamic acid (MFA) and aceclofenac (ALF) with α- and β-cyclodextrins (CDs) in aqueous medium were investigated by absorption, fluorescence, time-resolved fluorescence methods. The solid inclusion complexes between drugs and CDs were characterized by SEM, TEM, FT-IR, 1 H NMR, DSC and powder XRD techniques. Spectral studies indicated that both CDs form 1:1 inclusion complex with MFA and ALF. The experimental results revealed that the inclusion process is a spontaneous process. Time-resolved fluorescence studies suggested that ALF exhibited biexponential decay in aqueous and triexponential decay in CD whereas significant enhancement of lifetime of decay components of MFA was observed. Morphologies of drug-CD complexes observed by TEM demonstrate that self-aggregates of MFA/α-CD, ALF/α-CD and ALF/β-CD were nano-sized particles while vesicles were observed for MFA/β-CD. A spatial arrangement of inclusion complex is proposed based on 1 H NMR and PM3 results. Investigations of thermodynamic and electronic properties confirmed the stability of the inclusion complex. Highlights MFA and ALF drugs formed 1:1 inclusion complex with α-CD and β-CD at pH∼1 and pH∼7. Phenyl ring (COOH group substituted) is present in the hydrophilic part of the CD. Complex formation was confirmed by SEM, FTIR, 1 H NMR, DSC and XRD methods. Nanostructures were observed from drug-CD complex in the presence of water by TEM. Hydrogen bonds play a major role in the inclusion process. Graphical abstract TEM photographs of (a) MFA/α-CD nanoparticles and (b) MFA/β-CD vesicles. [DISPLAY OMISSION]


  • 주제어

    Mefenamic acid .   Aceclofenac .   Cyclodextrin .   Inclusion complex .   TEM .   Molecular modeling.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기