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Chemosphere v.172, 2017년, pp.440 - 448   SCI SCIE SCOPUS
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Cytotoxic, genotoxic and mutagenic evaluation of surface waters from a coal exploration region

Porta, Cynthia Silva (Post-Graduation Program in Molecular and Cellular Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil ) ; dos Santos, Débora Lemes (Post-Graduation Program in Molecular and Cellular Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil ) ; Bernardes, Hélio Vieira (Post-Graduation Program in Molecular and Cellular Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil ) ; Bellagamba, Bruno Corrêa (Post-Graduation Program in Molecular and Cellular Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil ) ; Duarte, Anaí (Ion Implantation Laboratory, Institute of Physics, UFRGS, Porto Alegre, RS, Brazil ) ; Dias, Johnny Ferraz (Ion Implantation Laboratory, Institute of Physics, UFRGS, Porto Alegre, RS, Brazil ) ; da Silva, Fernanda Rabaioli (Centro Universitário La Salle, Master's Degree in Environmental Impact Evaluation, Canoas, RS, Brazil ) ; Lehmann, Mauricio (Post-Graduation Program in Molecular and Cellular Biology Applied to Health, Lutheran University of Brazil (ULBRA), Canoas, RS, Brazil ) ; da Silva, Juliana (Post-Graduation Program in Molecul ) ; Dihl, Rafael Rodrigues ;
  • 초록  

    Abstract Coal mining generates a considerable amount of waste, which is disposed of in piles or dams near mining sites. As a result, leachates may reach rivers and streams, promoting the wide dispersion of contaminants in solution and as particulate matter. The present study evaluated the cytotoxic, genotoxic, and mutagenic action of surface waters collected around a thermoelectric power plant and the largest mining area in Brazil (Candiota). Four sites in Candiota stream were selected, and samples were collected in winter and summer. Water samples were analyzed using the comet and CBMN assays in V79 and HepG2 cells. Furthermore, genotoxicity of water samples was evaluated in vivo using the SMART in Drosophila melanogaster . In addition, polycyclic aromatic hydrocarbons and inorganic elements were quantified. The results indicate that water samples exhibited no genotoxic and mutagenic activities, whether in vitro or in vivo . On the other hand, surface water samples collected in sites near the power plant in both summer and winter inhibited cell proliferation and induced increased frequencies of V79 cell death, apoptosis, and necrosis. The cytotoxicity observed may be associated with the presence of higher concentration of inorganic elements, especially aluminum, silicon, sulfur, titanium and zinc at sites 1 and 2 in the stream, as well as with the complex mixture present in the coal, in both seasons. Therefore, the results obtained point to the toxicity potential of water samples with the influence of coal mining and combustion processes and the possible adverse effects on the health of exposed organisms. Highlights Toxicity of surface waters impacted by coal exploration was investigated in vivo and in vitro . Water samples inhibited cell proliferation. Water samples increased frequencies of V79 cell death, apoptosis, and necrosis. No genotoxic and mutagenic activities were observed. Graphical abstract [DISPLAY OMISSION]


  • 주제어

    Coal mining .   Chromosomal instability .   DNA damage .   Drosophila melanogaster .   V79 .   HepG2.  

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