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IEEE photonics journal v.9 no.1, 2017년, pp.1 - 10  

Enhanced Penetration of Human Placental Tissue by SiO$_{2}$ Nanoparticles as a Result of Microneedle and Electroporation Treatments

Gu, Panchun ; Wei, Huajiang ; Wu, Guoyong ; Guo, Zhouyi ; Yang, Hongqin ; He, Yonghong ; Xie, Shusen ;
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    The objective of this paper is to evaluate the penetration and accumulation of SiO $_{2}$ nanoparticles (NPs) in vitro human placental tissue as a function of NP size and electroporation (EP) and microneedle (MN) treatments. The results show that the penetration and accumulation of SiO $_{2}$ NPs has a significant influence on the optical properties. Optical coherence tomography (OCT) monitoring and diffuse reflectance (DR) spectra measurements indicate that 30 nm SiO $_{2}$ NPs have a tendency to generate greater signal intensities, while 15 nm NPs penetrated faster and had a higher penetration depth. The reduction in average attenuation coefficients of human placental tissue when the SiO $_{2}$ NPs size is constant is found to show the following trend: SiO $_{2}$ NPs in combination with EP and MN treatment $>$ SiO $_{2}$ NPs in combination with MN $>$ SiO $_{2}$ NPs with EP $>$ only SiO $_{2}$ NPs. It can be concluded that EP and MN treatments dramatically increase the penetration of SiO $_{2}$ NPs into human placental tissue. The results prove that OCT and DR spectra can be combined with EP and MN treatments to establish a theoretical basis for the safe use of SiO $_{2}$ NPs on human placental tissue and can potentially become a powerful tool for early diagnosis and monitoring of tissue diseases.


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