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Journal of controlled release : official journal of the Controlled Release Society v.247, 2017년, pp.86 - 105   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Topical and cutaneous delivery using nanosystems

Roberts, MS (Therapeutics Research Centre, School of Medicine, The University of Queensland, Translational Research Institute, QLD, 4102, Australia ); Mohammed, Y (Therapeutics Research Centre, School of Medicine, The University of Queensland, Translational Research Institute, QLD, 4102, Australia ); Pastore, MN (School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia ); Namjoshi, S (Therapeutics Research Centre, School of Medicine, The University of Queensland, Translational Research Institute, QLD, 4102, Australia ); Yousef, S (Therapeutics Research Centre, School of Medicine, The University of Queensland, Translational Research Institute, QLD, 4102, Australia ); Alinaghi, A (School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, Australia ); Haridass, IN (Therapeutics Research Centre, School of Medicine, The University of Queensland, Translational Research Institute, QLD, 4102, Australia ); Abd, E (Therapeutics Research Centre, School of Medicine, The University of Queensland, Translational Research Institute, QLD, 4102, Au ); Leite-Silva, VR ( ); Benson, HAE ( ); Grice, JE ( );
  • 초록  

    Abstract The goal of topical and cutaneous delivery is to deliver therapeutic and other substances to a desired target site in the skin at appropriate doses to achieve a safe and efficacious outcome. Normally, however, when the stratum corneum is intact and the skin barrier is uncompromised, this is limited to molecules that are relatively lipophilic, small and uncharged, thereby excluding many potentially useful therapeutic peptides, proteins, vaccines, gene fragments or drug-carrying particles. In this review we will describe how nanosystems are being increasingly exploited for topical and cutaneous delivery, particularly for these previously difficult substances. This is also being driven by the development of novel technologies, which include minimally invasive delivery systems and more precise fabrication techniques. While there is a vast array of nanosystems under development and many undergoing advanced clinical trials, relatively few have achieved full translation to clinical practice. This slow uptake may be due, in part, to the need for a rigorous demonstration of safety in these new nanotechnologies. Some of the safety aspects associated with nanosystems will be considered in this review. Graphical abstract [DISPLAY OMISSION]


  • 주제어

    Topical delivery .   Cutaneous delivery .   Nanosystems .   Nanoparticles .   Colloidal nanocarrier systems.  

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