본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Ceramics international v.43 no.6, 2017년, pp.4957 - 4964   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Magnetic lamellar nanohydroxyapatite as a novel nanocarrier for controlled delivery of 5-fluorouracil

Wan, Yizao (School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China ) ; Cui, Teng (School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China ) ; Xiong, Guangyao (School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China ) ; Li, Wei (School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China ) ; Tu, Junpin (School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China ) ; Zhu, Yong (School of Chemical Engineering, Tianjin University, Tianjin 300072, China ) ; Luo, Honglin (School of Materials Science and Engineering, East China Jiaotong University, Nanchang 330013, China ) ;
  • 초록  

    Abstract Magnetic nanoparticles are attractive carriers for drug delivery and layered materials intercalated by drug molecules exhibit improved safety and effectiveness of drug delivery. In this work, we report the loading of a model anticancer drug, 5-fluorouracil (5FU), into a magnetic layered nanohydroxyapatite (ML-HAP) by intercalation technique. The as-prepared ML-HAP nanoparticles with loaded 5FU were characterized using transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), and vibrating sample magnetometer. We find that, within a certain drug concentration, the drug molecules can be intercalated into the gallery of ML-HAP without breaking its lamellar structure. The drug loading capacity of ML-HAP is extremely large. The drug release profiles display pH-dependent behavior and the drug release mechanisms are a combination of drug diffusion and HAP dissolution. Furthermore, ML-HAP/5FU shows strong superparamagnetism and good biocompatibility. The ML-HAP can be an efficient platform for targeted anticancer drug delivery.


  • 주제어

    Layered hydroxyapatite .   5-fluorouracil .   Intercalation .   Controlled release.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기