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CNS neuroscience & therapeutics v.22 no.11, 2016년, pp.928 - 935   SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Sleep Complaints and the 24‐h Melatonin Level in Individuals with Smith–Magenis Syndrome: Assessment for Effective Intervention

Spruyt, Karen (Governor Kremers Center‐Rett Expertise Center & MHeNs, Maastricht University, Maastricht, Netherlands<country scheme="USMARC"> ); Braam, Wiebe (ne</country> ); Smits, Marcel (Governor Kremers Center‐Rett Expertise Center & MHeNs, Maastricht University, Maastricht, Netherlands<country scheme="USMARC"> ); Curfs, Leopold MG (ne</country> );
  • 초록  

    Summary Aims Individuals with Smith–Magenis syndrome (SMS) are reported to have a disrupted circadian rhythm. Our aim was to examine problematic sleeping in those attending our sleep clinic for the first time. Methods At intake, caregivers of 50 children and nine adults with SMS were surveyed about the sleep pattern and potential melatonin administration. Sampling of salivary melatonin levels was performed. Results At intake, exogenous melatonin was used by 16 children (27.1% of sample; 56.3% male) with mean age 6.8 ± 2.8 years, whereas 34 children (57.6%; 7.5 ± 4.8 years old; 64.7% male) and nine adults (15.3%; 36.8 ± 15.3 years old; 44.4% male) were not taking melatonin at intake. Participants were reported to have problems with night waking and early awakenings regardless of melatonin administration. Overall, moderate to high levels of salivary melatonin at noon were found in individuals with SMS. In particular, children with SMS showed a disrupted melatonin pattern. Furthermore, the endogenous melatonin level, age, and gender may potentially interact, yielding the severity range of sleep disturbances reported in SMS. Conclusion Treatment of sleep problems in SMS is complex, and our findings may support person‐centered sleep and medication management. Future clinical trials including larger groups may shed light on such approaches.


  • 주제어

    Awakening .   Circadian rhythm .   Insomnia .   Melatonin .   Sleep .   Sleep onset .   Smith–Magenis syndrome.  

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