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Journal of clinical periodontology v.44 no.2, 2017년, pp.150 - 157   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

The role of platelets in inflammatory immune responses in generalized aggressive periodontitis

Zhan, Yalin (Department of Periodontology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, China ) ; Lu, Ruifang (Department of Periodontology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, China ) ; Meng, Huanxin (Department of Periodontology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology, Beijing, China ) ; Wang, Xian'e (Department of Periodontology, Peking University School and Hospital of Stomatology & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key La ) ; Sun, Xiaojun ; Hou, Jianxia ;
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    Abstract Aim To investigate the relationship between inflammatory markers and platelet size in generalized aggressive periodontitis (GAgP). Material and Methods Periodontal, inflammatory and platelet indices were compared between 59 GAgP patients and 59 healthy subjects. Gingival biopsies from five patients and five healthy subjects were examined by immunohistochemistry and electron microscopy. Changes in patient periodontal and platelet indices were re‐evaluated at 3 months after periodontal therapy. Results Platelet size was decreased significantly in GAgP patients compared to healthy subjects ( p ≤ 0.003). Weak negative correlations between platelet size and periodontal parameters were found in GAgP patients ( p ≤ 0.025). Platelet aggregates and adhesion to the endothelium or leucocytes were found in venules and connective tissues of gingival biopsies from GAgP patients. Mean platelet volume (MPV) and platelet large cell ratio increased after periodontal therapy in GAgP patients ( p ≤ 0.038). The increase in MPV was related to the decrease in bleeding index in GAgP patients after periodontal therapy ( p 0.001; r =< 0.357). Conclusion Platelet size was reduced in GAgP patients compared to healthy controls, possibly due to the consumption of large platelets at sites of periodontal inflammation. Platelets may be involved in host responses to periodontal infection in GAgP.


  • 주제어

    generalized aggressive periodontitis .   inflammation .   mean platelet volume .   platelet large cell ratio.  

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