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Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association v.125 no.1, 2017년, pp.12 - 20   SCI SCIE
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Serum Ferritin, Insulin Resistance, and β-cell Dysfunction: A Prospective Study in Normoglycemic Japanese Men

Nakamura, Koshi (Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan ) ; Sakurai, Masaru (Department of Social and Environmental Medicine, Kanazawa Medical University, Uchinada, Japan ) ; Morikawa, Yuko (School of Nursing, Kanazawa Medical University, Uchinada, Japan ) ; Nagasawa, Shinya (Department of Epidemiology and Public Health, Kanazawa Medical University, Uchinada, Japan ) ; Miura, Katsuyuki (Department of Public Health, and Center for Epidemiologic Research in Asia, Shiga University of Medical Science, Otsu, Japan ) ; Ishizaki, Masao (Department of Social and Environmental Medicine, Kanazawa Medical University, Uchinada, Japan ) ; Kido, Teruhiko (School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan ) ; Naruse, Yuchi (Department of Social Walfare, Toyama College of Welfare Science, Imizu, Japan ) ; Nakashima, Motoko (School of Nursing, Kanazawa Medical University, Uchinada, Japan ) ; Nogawa, Kazuhiro (Department of Occupational and Environmental Medicine, Graduate School of Medicine, Chiba University, Chiba, Japan ) ; Suwazono, Yasushi (Department of Occupational and Environment ) ; Nakagawa, Hideaki ;
  • 초록  

    Objectives: The present cohort study investigated the relationship between serum ferritin levels and indices of insulin resistance and β-cell dysfunction in a normoglycemic population without iron overload disorders.Methods: The study participants included 575 normoglycemic Japanese men aged 35–57 years with serum ferritin levels of 400 μg/L or less. Insulin resistance and β-cell dysfunction were estimated at baseline and after 3 years by the homeostasis model assessments of insulin resistance and β-cell function (HOMA-IR and HOMA-β, respectively). To compare the subsequent changes in HOMA-IR and HOMA-β over a 3-year follow-up period among 3 groups based on tertiles of baseline serum ferritin levels (4.9–87.1, 87.2–140.5, and 140.6–396.8 μg/L), the geometric mean HOMA-IR and HOMA-β values at year 3 were calculated for each group using analysis of covariance, incorporating the respective log-transformed parameters at baseline in addition to age, body mass index and major confounding factors.Results: The multivariate-adjusted geometric mean HOMA-IR at year 3 was significantly higher in those in the highest and middle serum ferritin tertiles (1.24 and 1.22, respectively), compared with the lowest tertile (1.07) (p=0.009). When the total study participants were stratified by median body mass index (22.72 kg/m2), similar positive relationships were observed between serum ferritin levels and HOMA-IR for both obese and non-obese participants. However, the adjusted geometric mean HOMA-β at year 3 was similar among the 3 serum ferritin groups.Conclusions: Elevated serum ferritin levels predicted a subsequent increase in HOMA-IR in normoglycemic Japanese men without iron overload disorders.


  • 주제어

    serum ferritin .   homeostasis model assessment .   insulin resistance .   β-cell dysfunction .   epidemiology .   prospective study.  

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