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Diabetic medicine : a journal of the British Diabetic Association v.34 no.3, 2017년, pp.364 - 371   SCI SCIE
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High and low vitamin D level is associated with cardiovascular autonomic neuropathy in people with Type 1 and Type 2 diabetes

Hansen, C. S. (Department of Clinical Epidemiology, Steno Diabetes Centre A/S, Gentofte ) ; Fleischer, J. (Medical Research Laboratories, Clinical Institute of Medicine, Aarhus University, Aarhus ) ; Vistisen, D. (Department of Clinical Epidemiology, Steno Diabetes Centre A/S, Gentofte ) ; Ridderstråle, M. (Patient Care Centre, Steno Diabetes Centre A/S, Gentofte ) ; Jensen, J. S. (Department of Cardiology, Gentofte Hospital, Gentofte ) ; Jørgensen, M. E. (Department of Clinical Epidemiology, Steno Diabetes Centre A/S, Gentofte ) ;
  • 초록  

    Abstract Aim To investigate the possible association between vitamin D deficiency and cardiovascular autonomic neuropathy in people with diabetes. Methods A total of 113 people with Type 1 or Type 2 diabetes [mean (interquartile range) diabetes duration 22.0 (12–31) years, mean ( sd ) age 56.2 (13.0) years, 58% men] underwent vitamin D (D2 and D3) assessment, and were screened for cardiovascular autonomic neuropathy using three cardiovascular reflex tests [heart rate response to deep breathing (E/I ratio), to standing (30/15 ratio) and to the Valsalva manoeuvre] and assessment of 5‐min resting heart rate and heart rate variability indices. Results We found an inverse U‐shaped association between serum vitamin D level and E/I ratio, 30/15 ratio and three heart rate variability indices ( P P Conclusions High and low vitamin D levels were associated with cardiovascular autonomic neuropathy in people with diabetes. Future studies should explore this association and the efficacy of treating dysvitaminosis D to prevent cardiovascular autonomic neuropathy.


    What's new? The study presents a novel and previously undescribed significant inverse U‐shaped association between serum levels of vitamin D and measures of diabetic cardiovascular autonomic neuropathy.The study findings suggest that screening for vitamin D deficiency may be justified in people with diabetes.The study highlights the need for mechanistic studies investigating the possible pathological association between serum vitamin D levels and diabetic cardiovascular autonomic neuropathy and also the need for interventional trials investigating the efficacy of vitamin D supplementation in the treatment or prevention of the complication.


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