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GLIA v.65 no.4, 2017년, pp.606 - 638   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

The glia of the adult Drosophila nervous system

Kremer, Malte C. (Gene Center and Department of Biochemistry, Center of Protein Science Munich (CIPSM), Ludwig‐Maximilians‐University Munich, Germany ) ; Jung, Christophe (Gene Center and Department of Biochemistry, Center of Protein Science Munich (CIPSM), Ludwig‐Maximilians‐University Munich, Germany ) ; Batelli, Sara (Gene Center and Department of Biochemistry, Center of Protein Science Munich (CIPSM), Ludwig‐Maximilians‐University Munich, Germany ) ; Rubin, Gerald M. (Janelia Research Campus, Howard Hughes Medical Institute, Helix Drive, Ashburn, Virginia ) ; Gaul, Ulrike (Gene Center and Department of Biochemistry, Center of Protein Science Munich (CIPSM), Ludwig‐Maximilians‐University Munich, Germany ) ;
  • 초록  

    Glia play crucial roles in the development and homeostasis of the nervous system. While the GLIA in the Drosophila embryo have been well characterized, their study in the adult nervous system has been limited. Here, we present a detailed description of the glia in the adult nervous system, based on the analysis of some 500 glial drivers we identified within a collection of synthetic GAL4 lines. We find that glia make up ∼10% of the cells in the nervous system and envelop all compartments of neurons (soma, dendrites, axons) as well as the nervous system as a whole. Our morphological analysis suggests a set of simple rules governing the morphogenesis of glia and their interactions with other cells. All glial subtypes minimize contact with their glial neighbors but maximize their contact with neurons and adapt their macromorphology and micromorphology to the neuronal entities they envelop. Finally, glial cells show no obvious spatial organization or registration with neuronal entities. Our detailed description of all glial subtypes and their regional specializations, together with the powerful genetic toolkit we provide, will facilitate the functional analysis of glia in the mature nervous system. GLIA 2017 GLIA 2017;65:606–638


    Main Points Glia envelop all compartments of a neuron and the nervous system as a whole. All glial subtypes minimize contact with their glial neighbors and maximize their contact with neurons, however, show no obvious registration with the neuronal entities.


  • 주제어

    glial subtypes .   morphology .   glial cell interaction .   GAL4 lines .   multicolor mosaic.  

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