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Head & neck v.39 no.3, 2017년, pp.476 - 485   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Inhibition of epithelial–mesenchymal transition by cetuximab via the EGFR‐GEP100‐Arf6‐AMAP1 pathway in head and neck cancer

Matsumoto, Yoshifumi (Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, Tokyo, Japan ) ; Sakurai, Hiroyuki (Departments of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan ) ; Kogashiwa, Yasunao (Department of Head and Neck Surgery and Otolaryngology, Saitama Medical University International Medical Center, Hidaka, Saitama, Japan ) ; Kimura, Toru (Departments of Pharmacology and Toxicology, Kyorin University School of Medicine, Tokyo, Japan ) ; Matsumoto, Yuma (Department of Otolaryngology, Head and Neck Surgery, Kyorin University School of Medicine, Tokyo, Japan ) ; Shionome, Takashi (Department of Partial Denture Prosthodontics, Nihon University School of Dentistry, Kanda, Chiyoda‐ku, Tokyo, Japan ) ; Asano, Masatake (Department of Pathology, Nihon University School of Dentistry, Tokyo, Japan, Kanda, Chiyoda‐ku, ) ; Saito, Koichiro ; Kohno, Naoyuki ;
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    Abstract Background Despite improved survival by the addition of a monoclonal antibody against epidermal growth factor receptor (EGFR), cetuximab, to chemotherapy or radiotherapy for squamous cell carcinoma of the head and neck (SCCHN), cetuximab by itself is not a potent antiproliferative agent against SCCHN. We aimed to elucidate working mechanism of cetuximab in SCCHN. Methods The effect of cetuximab on the proliferation, migration, invasion, epithelial‐mesenchymal transition, and signaling events downstream of the EGFR were investigated in 4 SCCHN cell lines. The in vivo efficacy of cetuximab was evaluated in a xenotransplant model. Results Cetuximab inhibited migration, invasion, epithelial‐mesenchymal transition, and lymph node metastasis by suppressing EGFR‐GEP100‐Arf6‐AMAP1 pathway, but it did not inhibit cancer cell proliferation. Conclusion The improved survival by the addition of cetuximab is likely to be attributable to the antiepithelial‐mesenchymal transition action of cetuximab via inhibiting EGFR‐GEP100‐Arf6‐AMAP1 pathway. ⓒ 2016 Wiley Periodicals, Inc. Head Neck 39: 476–485, 2017


  • 주제어

    cetuximab .   GEP100 .   AMAP1 .   epithelial‐mesenchymal transition .   head and neck.  

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