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Head & neck v.39 no.3, 2017년, pp.548 - 554   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Correlative study of dose to thyroid and incidence of subsequent dysfunction after head and neck radiation

Ling, Stella (Department of Radiation Oncology, The Ohio State University, Columbus, Ohio ) ; Bhatt, Aashish D. (Department of Radiation Oncology, The Ohio State University, Columbus, Ohio ) ; Brown, Nicole V. (Department of Biomedical Informatics, The Ohio State University, Columbus, Ohio ) ; Nguyen, Phuong (Department of Radiation Oncology, The Ohio State University, Columbus, Ohio ) ; Sipos, Jennifer A. (Department of Endocrinology, The Ohio State University, Columbus, Ohio ) ; Chakravarti, Arnab (Department of Radiation Oncology, The Ohio State University, Columbus, Ohio ) ; Rong, Yi (Department of Radiation Oncology, The Ohio State University, Columbus, Ohio ) ;
  • 초록  

    ABSTRACT Background Thyroid dysfunction is common after radiotherapy (RT) for patients with head and neck cancers. We attempted to discover RT dose parameters that correspond with RT‐induced thyroid dysfunction. Methods Records of 102 patients who received RT from 2008 to 2010 were reviewed with respect to thyroid function. Abnormalities were grouped in 2 ways: (1) none, transient, or permanent; and (2) overt or subclinical. Results At median follow‐up of 33.5 months, incidence of any thyroid abnormality was 39.2% (women vs men – 50% vs 35%). Permanent dysfunction was seen in 24.5% with higher incidence in women versus men (42.9% vs 17.6%; p = .0081). Permanent abnormalities most strongly correlated with D 50% ( p = .0275). V 50Gy also correlated with thyroid dysfunction post‐RT ( p = .0316). Concurrent chemotherapy increased permanent dysfunction ( p = .0008). Conclusion Achieving D 50% 50 Head Neck 39: 548–554, 2017


  • 주제어

    thyroid abnormality .   hypothyroidism .   head and neck radiotherapy .   radiation dose volume histogram (DVH) .   radiation toxicity.  

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