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Head & neck v.39 no.3, 2017년, pp.533 - 540   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Reirradiation with intensity‐modulated radiotherapy for locally recurrent T3 to T4 nasopharyngeal carcinoma

Chan, Oscar S. H. (Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong ) ; Sze, Henry C. K. (Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong ) ; Lee, Michael C. H. (Department of Medical Physics, Pamela Youde Nethersole Eastern Hospital, Hong Kong ) ; Chan, Lucy L. K. (Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong ) ; Chang, Amy T. Y. (Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong ) ; Lee, Sarah W. M. (Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong ) ; Hung, Wai Man (Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong ) ; Lee, Anne W. M. (Department of Clinical Oncology, University of Hong Kong, Hong Kong ) ; Ng, Wai Tong (Department of Clini ) ;
  • 초록  

    ABSTRACT Background The purpose of this study was to assess the efficacy and toxicities of reirradiation using intensity‐modulated radiotherapy (IMRT) in patients with locally advanced recurrent nasopharyngeal carcinoma (NPC). Methods Thirty‐eight patients with consecutive rT3 to rT4 NPC treated between 2005 and 2013 were retrospectively analyzed. Results The 3‐year overall survival (OS), progression‐free survival (PFS), and local control rate were 47.2%, 17.5%, and 44.3%, respectively. Gross target volume (GTV) D 95 , GTV D 50 , and age were all important prognostic factors for OS and PFS, but only GTV D 95 was an important determinant for local control. A total of 73.7% patients experienced ≥1 grade 3 late toxicities and 3 patients died of massive epistaxis. Temporal lobe necrosis (TLN) developed sooner with a higher total biological equivalent dose. Conclusion Adequate tumor dose coverage was important for treating rT3 to rT4 NPC. Although late complications were common, treatment‐related mortality was solely vascular in nature. Dose constraints of neurologic structures for reirradiation should be revised with the latest information on late toxicities. ⓒ 2016 Wiley Periodicals, Inc. Head Neck 39: 533–540, 2017


  • 주제어

    reirradiation .   local recurrence .   nasopharyngeal carcinoma .   intensity‐modulated radiotherapy .   toxicities.  

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