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Head & neck v.39 no.3, 2017년, pp.527 - 532   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Cardiovascular risk and prevention in patients with head and neck cancer treated with radiotherapy

Okoye, Christian C. (Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, Cleveland, Ohio ) ; Bucher, Jessica (Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, Ohio ) ; Tatsuoka, Curtis (Department of Neurology, University Hospitals Cleveland Medical Center, Cleveland, Ohio ) ; Parikh, Sahil A. (Harrington Heart and Vascular Institute, Department of Internal Medicine ‐ ) ; Oliveira, Guilherme H. (Cardiology, University Hospitals, Case Western Reserve University, Cleveland, Ohio ) ; Gibson, Michael K. (Onco‐Cardiology Program, and Advanced Heart Failure and Transplant Center, Harrington Heart and Vascular Institute, Department of Internal Medicine, University Hospitals, Case Western Reserve University, Cleveland, Ohio ) ; Machtay, Mitchell (Division of Hematology and Oncology, Department of Medicine, University Hospitals, Case Western Rese ) ; Yao, Min ; Zender, Chad A. ; Dorth, Jennifer A. ;
  • 초록  

    Abstract Background The underlying contributors to cardiovascular disease (CVD) in patients with head and neck squamous cell carcinoma (HNSCC) are poorly characterized. Methods Patients with HNSCC who underwent definitive or adjuvant (chemo)radiation between 2011 and 2013 were retrospectively reviewed. The 10‐year risk estimates for a CVD event were calculated according to the Framingham Risk Score (FRS). Results One hundred fifteen patients with predominantly stage III/IV HNSCC had a median follow‐up of 2 years. At diagnosis, 23% of patients had CVD. The FRS was higher among patients with laryngeal cancer versus other sites (20.5% vs 14.4%). Twenty‐four percent of all patients had uncontrolled blood pressure at diagnosis. Among the patients with CVD, 41% were not taking antiplatelet therapy and 30% were not taking statin therapy. Thirty‐four percent of patients without CVD had indications for initiating statin therapy. Conclusion Patients with HNSCC have a high baseline CVD risk and many do not receive optimal preventive care. ⓒ 2016 Wiley Periodicals, Inc. Head Neck 39: 527–532, 2017


  • 주제어

    primary prevention .   cardiovascular disease .   risk factors .   head and neck cancer .   radiotherapy.  

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