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Head & neck v.39 no.3, 2017년, pp.492 - 497   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Use of pretreatment serum uric acid level to predict metastasis in locally advanced nasopharyngeal carcinoma

Du, Xiao‐Jing (Department of Radiation Oncology, Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China ) ; Chen, Lei (Department of Radiation Oncology, Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China ) ; Li, Wen‐Fei (Department of Radiation Oncology, Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China ) ; Tang, Ling‐Long (Department of Radiation Oncology, Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China<coun ) ; Mao, Yan‐Ping ; Guo, Rui ; Sun, Ying ; Lin, Ai‐Hua ; Ma, Jun ;
  • 초록  

    Abstract Background The purpose of this study was to determine the predictive value of pretreatment serum uric acid (SUA) for metastasis in locally advanced nasopharyngeal carcinoma (NPC) treated with intensity‐modulated radiotherapy. Methods This retrospective study examined 1063 patients with locally advanced NPC. Multivariate survival analysis was used. Results High pretreatment SUA level (>353.4 μmol/L) independently predicted distant metastasis‐free survival ( p = .013) and was associated with high white blood cell ( p = .005), lymphocyte counts ( p p p = .042). For patients with subsequent lung metastases after treatment, markedly higher pretreatment SUA levels were detected compared with patients who had other distant metastases ( p = .012) and patients without distant metastasis ( p = .024). Conclusion Pretreatment SUA may be a useful biomarker for evaluating treatment options for patients with locally advanced NPC. ⓒ 2016 Wiley Periodicals, Inc. Head Neck 39: 492–497, 2017


  • 주제어

    uric acid .   nasopharyngeal carcinoma .   prognosis .   metastasis .   intensity‐modulated radiotherapy.  

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