본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Hippocampus v.27 no.3, 2017년, pp.249 - 262   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy

Fiford, Cassidy M. (Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom ) ; Manning, Emily N. (Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom ) ; Bartlett, Jonathan W. (Statistical Innovation Group, Cambridge, AstraZeneca, United Kingdom ) ; Cash, David M. (Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom ) ; Malone, Ian B. (Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, United Kingdom ) ; Ridgway, Gerard R. (Nuffield Department of Clinical Neurosciences, FMRIB Centre, University of Oxford, United Kingdom ) ; Lehmann, Manja (Department of Neurodegenerative Disease, Dementia Research Centre, UCL Institute of Neurology, London, United Kingd ) ; Leung, Kelvin K. ; Sudre, Carole H. ; Ourselin, Sebastien ; Biessels, Geert Jan ; Carmichael, Owen T. ; Fox, Nick C. ; Cardoso, M. Jorge ; Barnes, Josephine ;
  • 초록  

    ABSTRACT This study investigates relationships between white matter hyperintensity (WMH) volume, cerebrospinal fluid (CSF) Alzheimer's disease (AD) pathology markers, and brain and hippocampal volume loss. Subjects included 198 controls, 345 mild cognitive impairment (MCI), and 154 AD subjects with serial volumetric 1.5‐T MRI. CSF Aβ 42 and total tau were measured ( n = 353). Brain and hippocampal loss were quantified from serial MRI using the boundary shift integral (BSI). Multiple linear regression models assessed the relationships between WMHs and hippocampal and brain atrophy rates. Models were refitted adjusting for (a) concurrent brain/hippocampal atrophy rates and (b) CSF Aβ 42 and tau in subjects with CSF data. WMH burden was positively associated with hippocampal atrophy rate in controls ( P = 0.002) and MCI subjects ( P = 0.03), and with brain atrophy rate in controls ( P = 0.03). The associations with hippocampal atrophy rate remained following adjustment for concurrent brain atrophy rate in controls and MCIs, and for CSF biomarkers in controls ( P = 0.007). These novel results suggest that vascular damage alongside AD pathology is associated with disproportionately greater hippocampal atrophy in nondemented older adults. ⓒ 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc.


  • 주제어

    Alzheimer's disease .   vascular disease .   mild cognitive impairment .   hippocampus .   white matter hyperintensity (WMH) .   white matter disease.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기