본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Heart : official journal of the British Cardiac Society v.103 no.5, 2017년, pp.368 - 376   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Long-term efficacy of catheter ablation as first-line therapy for paroxysmal atrial fibrillation: 5-year outcome in a randomised clinical trial

Nielsen, Jens Cosedis (Department of Cardiology, Aarhus University Hospital, , Aarhus N, Denmark ) ; Johannessen, Arne (Gentofte University Hospital, , Copenhagen, Denmark ) ; Raatikainen, Pekka (Heart Center Co. Tampere University Hospital, , Tampere, Finland ) ; Hindricks, Gerhard (Leipzig University Hospital, , Leipzig, Germany ) ; Walfridsson, Håkan (Department of Cardiology, Linkoping University, , Linkoping, Sweden ) ; Pehrson, Steen Michael (Department of Cardiology, The Heart Center, Rigshospitalet, , Copenhagen, Denmark ) ; Englund, Anders (Department of Medicine, University Hospital, , Orebro, Sweden ) ; Hartikainen, Juha (Kuopio University Hospital, , Kuopio, Finland ) ; Mortensen, Leif Spange (UNI-C, Danish Information Technology Centre for Education and Research, , Aarhus, Denmark ) ; Hansen, Peter Steen (Department of Cardiology, Aarhus University Hospital, , Aarhus N, Denmark ) ;
  • 초록  

    Objective The Medical ANtiarrhythmic Treatment or Radiofrequency Ablation in Paroxysmal Atrial Fibrillation (MANTRA-PAF) trial compared radiofrequency catheter ablation (RFA) with antiarrhythmic drug therapy (AAD) as first-line treatment for paroxysmal atrial fibrillation (AF). Endpoint of ablation was elimination of electrical activity inside pulmonary veins. We present the results of the 5-year follow-up. Methods This pre-specified 5-year follow-up included assessment of any AF and symptomatic AF burden by one 7-day Holter recording and quality of life (QoL) assessment, using SF-36 questionnaire physical and mental component scores. Analysis was intention-to-treat. Imputation was used to compensate for missing Holter data. Results 245 of 294 patients (83%) randomised to RFA (n=125) or AAD (n=120) attended the 5-year follow-up, 227 with Holter recording. Use of class I or III AAD was more frequent in AAD group (N=61 vs 13, p<0.001). More patients in the RFA group were free from AF (126/146 (86%) vs 105/148 (71%), p=0.001, relative risk (RR) 0.82; 95% CI 0.73 to 0.93) and symptomatic AF (137/146 (94%) vs 126/148 (85%), p=0.015, χ 2 test, RR 0.91; 95% CI 0.84 to 0.98) in 7-day Holter recording. AF burden was significantly lower in the RFA group (any AF: p=0.003; symptomatic AF: p=0.02). QoL scores did not differ between randomisation groups. QoL scores remained improved from baseline (both components p<0.001), and did not differ from 2-year scores. Conclusions At 5 years, the occurrence and burden of any AF and symptomatic AF were significantly lower in the RFA group than in the AAD group. Improved QoL scores observed after 2 years persisted after 5 years without between-group differences. Trial registration number NCT00133211; Results.


  • 주제어

    Catheter ablation.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기