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The Journal of biological chemistry v.292 no.7, 2017년, pp.2646 - 2659   SCI SCIE
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c-JUN Dimerization Protein 2 (JDP2) Is a Transcriptional Repressor of Follicle-stimulating Hormone β (FSHβ) and Is Required for Preventing Premature Reproductive Senescence in Female Mice

Jonak, Carrie R. (From the Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California 92521 ) ; Lainez, Nancy M. (From the Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California 92521 ) ; Roybal, Lacey L. (From the Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California 92521 ) ; Williamson, Alexa D. (From the Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California 92521 ) ; Coss, Djurdjica (From the Division of Biomedical Sciences, School of Medicine, University of California, Riverside, California 92521 ) ;
  • 초록  

    Follicle-stimulating hormone (FSH) regulates follicular growth and stimulates estrogen synthesis in the ovaries. FSH is a heterodimer consisting of an α subunit, also present in luteinizing hormone, and a unique β subunit, which is transcriptionally regulated by gonadotropin-releasing hormone 1 (GNRH). Because most FSH is constitutively secreted, tight transcriptional regulation is critical for maintaining FSH levels within a narrow physiological range. Previously, we reported that GNRH induces FSHβ ( Fshb ) transcription via induction of the AP-1 transcription factor, a heterodimer of c-FOS and c-JUN. Herein, we identify c-JUN-dimerization protein 2 (JDP2) as a novel repressor of GNRH-mediated Fshb induction. JDP2 exhibited high basal expression and bound the Fshb promoter at an AP-1-binding site in a complex with c-JUN. GNRH treatment induced c-FOS to replace JDP2 as a c-JUN binding partner, forming transcriptionally active AP-1. Subsequently, rapid c-FOS degradation enabled reformation of the JDP2 complex. In vivo studies revealed that JDP2 null male mice have normal reproductive function, as expected from a negative regulator of the FSH hormone. Female JDP2 null mice, however, exhibited early puberty, observed as early vaginal opening, larger litters, and early reproductive senescence. JDP2 null females had increased levels of circulating FSH and higher expression of the Fshb subunit in the pituitary, resulting in elevated serum estrogen and higher numbers of large ovarian follicles. Disruption of JDP2 function therefore appears to cause early cessation of reproductive function, a condition that has been associated with elevated FSH in women.


  • 주제어

    AP-1 transcription factor (AP-1) .   c-FOS .   c-JUN transcription factor .   endocrinology .   follicle-stimulating hormone (FSH) .   gene expression .   gene transcription.  

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