본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

The Journal of biological chemistry v.292 no.7, 2017년, pp.2754 - 2772   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Inhibition of Ubc13-mediated Ubiquitination by GPS2 Regulates Multiple Stages of B Cell Development

Lentucci, Claudia (From the Departments of Biochemistry, ) ; Belkina, Anna C. (the Flow Cytometry Core Facility, Boston University School of Medicine, Boston, Massachusetts 02118 and ) ; Cederquist, Carly T. (From the Departments of Biochemistry, ) ; Chan, Michelle (From the Departments of Biochemistry, ) ; Johnson, Holly E. (From the Departments of Biochemistry, ) ; Prasad, Sherry (From the Departments of Biochemistry, ) ; Lopacinski, Amanda (From the Departments of Biochemistry, ) ; Nikolajczyk, Barbara S. (Microbiology, and ) ; Monti, Stefano (Medicine and ) ; Snyder-Cappione, Jennifer (the Flow Cytometry Core Facility, Boston University School of Medicine, Boston, Massachusetts 02118 and ) ; Tanasa, Bogdan (the Department of Pediatrics, Stanford University School of Medicine, Stanford, California 94305 ) ; Cardamone, M. Dafne (From the Departments of Biochemistry, ) ; Perissi, Valentina (From the Departments of Biochemistry, ) ;
  • 초록  

    Non-proteolytic ubiquitin signaling mediated by Lys 63 ubiquitin chains plays a critical role in multiple pathways that are key to the development and activation of immune cells. Our previous work indicates that GPS2 (G-protein Pathway Suppressor 2) is a multifunctional protein regulating TNFα signaling and lipid metabolism in the adipose tissue through modulation of Lys 63 ubiquitination events. However, the full extent of GPS2-mediated regulation of ubiquitination and the underlying molecular mechanisms are unknown. Here, we report that GPS2 is required for restricting the activation of TLR and BCR signaling pathways and the AKT/FOXO1 pathway in immune cells based on direct inhibition of Ubc13 enzymatic activity. Relevance of this regulatory strategy is confirmed in vivo by B cell-targeted deletion of GPS2, resulting in developmental defects at multiple stages of B cell differentiation. Together, these findings reveal that GPS2 genomic and non-genomic functions are critical for the development and cellular homeostasis of B cells.


  • 주제어

    development .   Notch pathway .   toll-like receptor (TLR) .   ubiquitin .   ubiquitin-conjugating enzyme (E2 enzyme).  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기