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Journal of clinical pathology v.70 no.3, 2017년, pp.217 - 221   SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Cadherin 5 expression correlates with poor survival in human gastric cancer

Higuchi, Kyoko (Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, , Tokyo, Japan ) ; Inokuchi, Mikito (Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, , Tokyo, Japan ) ; Takagi, Yoko (Department of Surgical Specialties, Tokyo Medical and Dental University, , Tokyo, Japan ) ; Ishikawa, Toshiaki (Department of Surgical Specialties, Tokyo Medical and Dental University, , Tokyo, Japan ) ; Otsuki, Sho (Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, , Tokyo, Japan ) ; Uetake, Hiroyuki (Department of Surgical Specialties, Tokyo Medical and Dental University, , Tokyo, Japan ) ; Kojima, Kazuyuki (Department of Minimally Invasive Surgery, Tokyo Medical and Dental University, , Tokyo, Japan ) ; Kawano, Tatsuyuki (Department of Gastrointestinal Surgery, Tokyo Medical and Dental University, , Tokyo, Japan ) ;
  • 초록  

    Aims Although expressed in tumour cells of various malignancies, cadherin 5 (CDH5), also known as vascular endothelial cadherin, plays an important role in homotypic cell–cell adhesion among epithelial cells. However, the clinical significance of CDH5 expression in gastric cancer has not been sufficiently demonstrated. In this study, CDH5 expression in gastric cancer was evaluated and the correlations between CDH5 expression and the clinicopathological features and outcomes of the disease were examined. Methods Differentiated-type gastric adenocarcinomas obtained from 102 patients who underwent gastrectomy were analysed. CDH5 expression was assessed by immunohistochemical staining of the membranes of the cancer cells. Results High CDH5 expression was significantly associated with the following clinicopathological variables related to tumour progression: depth of invasion (p=0.012), venous invasion (p=0.013), lymphatic invasion (p=0.001), metastatic lymph nodes (p=0.009), pathological stage (p=0.008) and distant metastasis or recurrent disease (p=0.009). Patients with high CDH5 expression had significantly poorer disease-specific survival (p=0.021), although CDH5 was not determined to be an independent prognostic factor by multivariate analysis. Conclusions CDH5 may play a key role in the progression or metastasis of differentiated-type gastric cancer and serve as a target for its treatment.


  • 주제어

    GASTRIC CANCER .   GASTRIC PATHOLOGY .   IMMUNOHISTOCHEMISTRY.  

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