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Scientific reports v.6, 2016년, pp.37498 -    SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Female gender lost protective effect against disease progression in elderly patients with chronic hepatitis B

You, Hong (Liver Research Center, Beijing Friendship Hospital, Capital Medical University ) ; Kong, Yuanyuan (Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis ) ; Hou, Jinlin (National Clinical Research Center for Digestive Disease, Beijing, 100050, China ) ; Wei, Lai (Liver Research Center, Beijing Friendship Hospital, Capital Medical University ) ; Zhang, Yuexin (Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis ) ; Niu, Junqi (National Clinical Research Center for Digestive Disease, Beijing, 100050, China ) ; Han, Tao (Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China ) ; Ou, Xiaojuan (Peking University People's Hospital, Beijing, 100044, China ) ; Dou, Xiaoguang (First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054, China ) ; Shang, Jia (First Hospital of Jilin University, Changchun, 130021, China ) ; Tang, Hong (Tianjin Third Central Hospital, Tianjin Medical University, Tianjin, 300170, China ) ; Xie, Qing (Liver Research Center, Beijing Friendship Hospital, Capital Medical University ) ; Ding, Huiguo (Beijing Key Laboratory of Translational Medicine on Liver Cirrhosis ) ; Ren, Hong (National Clinical Res ) ; Xu, Xiaoyuan ; Xie, Wen ; Liu, Xiaoqing ; Xu, Youqing ; Li, Yujie ; Li, Jie ; Chow, Shein-Chung ; Zhuang, Hui ; Jia, Jidong ;
  • 초록  

    Female gender and younger age are protective factors against disease progression in chronic hepatitis B (CHB). However, it is not clear whether the disease progression still remains slow in elderly females. This study investigated the interaction of female gender and older age on the development of cirrhosis in patients recorded in China Registry of Hepatitis B. A total of 17,809 CHB patients were enrolled in this multi-center cross-sectional study. The prevalence of cirrhosis in female CHB patients increased faster than that in male CHB patients over 50 years old. Multivariate analysis showed that the increase of adjusted ORs for developing cirrhosis in females started to accelerate after 50 years old: 11.19 (95% CI: 5.93–21.11) in women versus 14.75 (95% CI: 8.35–26.07) in men at ages of 50–59 years, 21.67 (95% CI: 11.05–42.47) versus 24.4 (95% CI: 13.00–45.80) at ages 60–69 years, and 18.78 (95% CI: 6.61–53.36) versus 12.09 (95% CI: 4.35–33.61) in those over 70 years. In conclusion, the protective effect of female gender against cirrhosis gradually lost with increasing age, therefore disease progression should be monitored more closely in elderly women with CHB.


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