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Scientific reports v.6, 2016년, pp.37924 -    SCI SCIE
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GWAS study using DNA pooling strategy identifies association of variant rs4910623 in OR52B4 gene with anti-VEGF treatment response in age-related macular degeneration

Riaz, Moeen (Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Australia ) ; Lorés-Motta, Laura (Ophthalmology, Department of Surgery, University of Melbourne, Australia ) ; Richardson, Andrea J. (Department of Ophthalmology, Donders Institute for Brain, Cognition and Behaviour, Radboud university medical center, Nijmegen, the Netherlands ) ; Lu, Yi (Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Australia ) ; Montgomery, Grant (Ophthalmology, Department of Surgery, University of Melbourne, Australia ) ; Omar, Amer (Statistical Genetics Laboratory, QIMR Berghofer Medical Research Institute, Brisbane, Australia ) ; Koenekoop, Robert K. (Molecular Epidemiology, QIMR Berghofer Medical Research Institute, Brisbane, Australia ) ; Chen, John (Montreal Retina Institute, Westmount, Canada ) ; Muether, Philipp (Paediatric Surgery, Human Genetics, and Ophthalmology, McGill University Health Centre, Montreal, Quebec, Canada ) ; Altay, Lebriz (Department of Ophthalmology, McGill University Health Centre, Montreal, Quebec, Canada ) ; Schick, Tina (Department of Ophthalmology, University Hospital of Cologne, Cologne, Germany ) ; Fauser, Sascha (Department of Op ) ; Smailhodzic, Dzenita ; van Asten, Freekje ; de Jong, Eiko K. ; Hoyng, Carel B. ; Burdon, Kathryn P. ; MacGregor, Stuart ; Guymer, Robyn H. ; den Hollander, Anneke I. ; Baird, Paul N. ;
  • 초록  

    Pooled DNA based GWAS to determine genetic association of SNPs with visual acuity (VA) outcome in anti-vascular endothelial growth factor (anti-VEGF) treated neovascular age-related macular degeneration (nAMD) patients. We performed pooled DNA based GWAS on 285 anti-VEGF treated nAMD patients using high density Illumina 4.3 M array. Primary outcome was change in VA in Early Treatment Diabetic Retinopathy Study (ETDRS) letters after 6 months of anti-VEGF treatment (patients who lost ≥5 ETDRS letters classified as non-responders and all remaining classified as responders). GWAS analysis identified 44 SNPs of interest: 37 with strong evidence of association (p  −8 ), 2 in drug resistance genes (p  −6 ) and 5 nonsynonymous changes (p  −4 ). In the validation phase, individual genotyping of 44 variants showed three SNPs (rs4910623 p = 5.6 × 10 −5 , rs323085 p = 6.5 × 10 −4 and rs10198937 p = 1.30 × 10 −3 ) remained associated with VA response at 6 months. SNP rs4910623 also associated with treatment response at 3 months (p = 1.5 × 10 −3 ). Replication of these three SNPs in 376 patients revealed association of rs4910623 with poor VA response after 3 and 6 months of treatment (p = 2.4 × 10 −3 and p = 3.5 × 10 −2 , respectively). Meta-analysis of both cohorts (673 samples) confirmed association of rs4910623 with poor VA response after 3 months (p = 1.2 × 10 −5 ) and 6 months (p = 9.3 × 10 −6 ) of treatment in nAMD patients.


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