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Scientific reports v.6, 2016년, pp.37933 -    SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

The clinicopathological and prognostic significance of PD-L1 expression in gastric cancer: a meta-analysis of 10 studies with 1,901 patients

Zhang, Minghui (Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China ) ; Dong, Yuandi (Department of Surgical Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China ) ; Liu, Haitao (Department of Intensive Care Unit, Harbin Medical University Cancer Hospital, Harbin 150081, China ) ; Wang, Yan (Department of Medical Oncology, Heilongjiang Provincial Hospital, Harbin 150000, China ) ; Zhao, Shu (Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China ) ; Xuan, Qijia (Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China ) ; Wang, Yan (Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China ) ; Zhang, Qingyuan (Department of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin 150081, China ) ;
  • 초록  

    The prognostic value of programmed death-ligand 1 (PD-L1) in gastric cancer (GC) remains controversial. To clarify this problem, we performed a meta-analysis of research studies identified in the PubMed, EMBASE and the Cochrane Library databases. A total of 1,901 patients in 10 studies were enrolled in this meta-analysis, and the pooled hazard ratio (HR) of 1.64 (95% CI 1.11 to 2.43; P = 0.01) indicated that PD-L1 expression is associated with a shorter overall survival (OS). The pooled odds ratios (ORs) indicated that PD-L1 expression was associated with tumour size (OR = 1.87, 95% CI 1.25 to 2.78; P = 0.002) and lymph node status (OR = 2.17, 95% CI 1.04 to 4.52; P = 0.04). However, PD-L1 had no correlation with gender, age, cancer location, differentiation, depth of invasion, and tumour stage. This meta-analysis indicates that PD-L1 expression is a valuable predictor of the prognosis of patients with GC. PD-L1 expression could be used for identifying a subgroup of patients, who would potentially benefit from targeted therapy against PD-1 or PD-L1. Well-designed large-cohort studies are needed to confirm these findings.


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