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Scientific reports v.6, 2016년, pp.37848 -    SCI SCIE
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Coulomb nanoradiator-mediated, site-specific thrombolytic proton treatment with a traversing pristine Bragg peak

Jeon, Jae-Kun (Departments of Biomedical Engineering, Catholic University of Daegu, School of Medicine, Daegu, Korea ) ; Han, Sung-Mi (Anatomy, and Diagnostic Imaging, Catholic University of Daegu, School of Medicine, Daegu, Korea ) ; Min, Soon-Ki (Catholic University of Daegu, School of Medicine, Daegu, Korea ) ; Seo, Seung-Jun (Departments of Biomedical Engineering, Catholic University of Daegu, School of Medicine, Daegu, Korea ) ; Ihm, Kyuwook (Pohang Accelerator Laboratory, Pohang, Korea ) ; Chang, Won-Seok (Departments of Biomedical Engineering, Catholic University of Daegu, School of Medicine, Daegu, Korea ) ; Kim, Jong-Ki (Departments of Biomedical Engineering, Catholic University of Daegu, School of Medicine, Daegu, Korea ) ;
  • 초록  

    Traversing proton beam-irradiated, mid/high-Z nanoparticles produce site-specific enhancement of X-ray photon-electron emission via the Coulomb nanoradiator (CNR) effect, resulting in a nano-to micro-scale therapeutic effect at the nanoparticle-uptake target site. Here, we demonstrate the uptake of iron oxide nanoparticles (IONs) and nanoradiator-mediated, site-specific thrombolysis without damaging the vascular endothelium in an arterial thrombosis mouse model. The enhancement of low-energy electron (LEE) emission and reactive oxygen species (ROS) production from traversing proton beam-irradiated IONs was examined. Flow recovery was only observed in CNR-treated mice, and greater than 50% removal of the thrombus was achieved. A 2.5-fold greater reduction in the thrombus-enabled flow recovery was observed in the CNR group compared with that observed in the untreated ION-only and proton-only control groups (p


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