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Diagnostics v.2 no.4, 2012년, pp.42 - 51  

Importance of Attenuation Correction (AC) for Small Animal PET Imaging

El Ali, Henrik H.   Bodholdt, Rasmus Poul   Jørgensen, Jesper Tranekjær   Myschetzky, Rebecca   Kjaer, Andreas  
  • 초록  

    The purpose of this study was to investigate whether a correction for annihilation photon attenuation in small objects such as mice is necessary. The attenuation recovery for specific organs and subcutaneous tumors was investigated. A comparison between different attenuation correction methods was performed. Methods : Ten NMRI nude mice with subcutaneous implantation of human breast cancer cells (MCF-7) were scanned consecutively in small animal PET and CT scanners (MicroPET TM Focus 120 and ImTek's MicroCAT TM II). CT-based AC, PET-based AC and uniform AC methods were compared. Results: The activity concentration in the same organ with and without AC revealed an overall attenuation recovery of 9–21% for MAP reconstructed images, i.e. , SUV without AC could underestimate the true activity at this level. For subcutaneous tumors, the attenuation was 13 ± 4% (9–17%), for kidneys 20 ± 1% (19–21%), and for bladder 18 ± 3% (15–21%). The FBP reconstructed images showed almost the same attenuation levels as the MAP reconstructed images for all organs. Conclusions: The annihilation photons are suffering attenuation even in small subjects. Both PET-based and CT-based are adequate as AC methods. The amplitude of the AC recovery could be overestimated using the uniform map. Therefore, application of a global attenuation factor on PET data might not be accurate for attenuation correction.


  • 주제어

    attenuation correction .   small animal .   PET imaging .   MicroPET .   molecular imaging.  

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