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Clinical immunology : the official journal of the Clinical Immunology Society v.183, 2017년, pp.8 - 16   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

High resolution IgH repertoire analysis reveals fetal liver as the likely origin of life-long, innate B lymphopoiesis in humans

Roy, Anindita (Department of Paediatrics, University of Oxford, Brno, Czech Republic ) ; Bystry, Vojtech (CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic ) ; Bohn, Georg (Centre for Haematology, Department of Medicine, Imperial College London, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK ) ; Goudevenou, Katerina (Centre for Haematology, Department of Medicine, Imperial College London, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK ) ; Reigl, Tomas (CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic ) ; Papaioannou, Maria (Centre for Haematology, Department of Medicine, Imperial College London, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK ) ; Krejci, Adam (Centre for Haematology, Department of Medicine, Imperial College London, Imperial College Healthcare NHS Trust, Hammersmith Hospital, London, UK ) ; O'Byrne, Sorcha (Department of Paediatrics, University of Oxford, Brno, Czech Republic ) ; Chaidos, Aristeidis (Centre for Haematology, Department of Medicine, Imperial College London, Imperia ) ; Grioni, Andrea ; Darzentas, Nikos ; Roberts, Irene A.G. ; Karadimitris, Anastasios ;
  • 초록  

    Abstract The ontogeny of the natural, public IgM repertoire remains incompletely explored. Here, high-resolution immunogenetic analysis of B cells from (unrelated) fetal, child, and adult samples, shows that although fetal liver (FL) and bone marrow (FBM) IgM repertoires are equally diversified, FL is the main source of IgM natural immunity during the 2nd trimester. Strikingly, 0.25% of all prenatal clonotypes, comprising 18.7% of the expressed repertoire, are shared with the postnatal samples, consistent with persisting fetal IgM+ B cells being a source of natural IgM repertoire in adult life. Further, the origins of specific stereotypic IgM+ B cell receptors associated with chronic lymphocytic leukemia, can be traced back to fetal B cell lymphopoiesis, suggesting that persisting fetal B cells can be subject to malignant transformation late in life. Overall, these novel data provide unique insights into the ontogeny of physiological and malignant B lymphopoiesis that spans the human lifetime. Highlights Second trimester human fetal liver and fetal bone marrow B-cells have IgM repertoires that are equally diversified Human fetal liver B-cells are the main source of innate, natural IgM responses CLL-associated, stereotypic B cell receptors are detected in fetal IgM repertoire Graphical abstract [DISPLAY OMISSION]


  • 주제어

    Human .   Fetal .   IgH repertoire.  

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