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Clinical immunology : the official journal of the Clinical Immunology Society v.183, 2017년, pp.46 - 53   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus

Xu, Bihua (Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ); Wang, Shuang (Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ); Zhou, Mianjing (Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ); Huang, Yuefang (Department of Pediatrics, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ); Fu, Rong (Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ); Guo, Chaohuan (Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ); Chen, Jingxian (Department of Pediatrics, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ); Zhao, Jijun (Department of Rheumatology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, PR China ); Gaskin, Felicia (Department of Psychiatry and Neurobehavioral Sciences, University of Virginia, Charlottesville, VA 22908-0133, USA ); Fu, Shu Man (Division of Rheumatolog ); Yang, Niansheng ( );
  • 초록  

    Abstract Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells mediated B cell responses. Tfh cells are involved in the pathogenesis of systemic lupus erythematosus (SLE). However, the role of Tfr cells in SLE remains unclear. The frequency of circulating Tfr and Tfh cells were examined in SLE patients and healthy controls. The frequency of circulating Tfr cell decreased and Tfh/Tfr ratio increased in SLE patients. Serum anti-dsDNA antibody level positively correlated with frequency of Tfh cells and Tfh/Tfr ratios but negatively correlated with the frequency of Tfr cells. Moreover, the frequency of Tfr and Tfh/Tfr ratio but not that of Tfh was correlated with diseases activity. In addition, increase in Tfr cell numbers and decrease in the Tfh/Tfr ratios were observed with successful treatments. Thus, Tfr cells should be considered as a biomarker for SLE and their role in the pathogenesis of SLE warrants further investigation. Highlights The frequency of circulating Tfr cells decreased and Tfh/Tfr ratio increased in SLE patients. Increased active subpopulation was found in Tfh and Tfr cells of SLE. The frequency of Tfr and Tfh/Tfr ratio but not that of Tfh was correlated with diseases activity. Increase in Tfr cell numbers and decrease in the Tfh/Tfr ratios were observed with successful treatments.


  • 주제어

    Tfh .   Tfr .   SLE .   Biomarker.  

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