Immunoglobulin and B-cell disturbances in patients with chronic idiopathic neutropenia
Abstract Chronic idiopathic neutropenia (CIN) is a granulocytic disorder associated with presence of activated, myelosuppressive T-lymphocytes. In the present study we have evaluated constituents of humoral immunity in CIN patients ( n = 48) compared to healthy controls ( n = 52). CIN patients displayed lower serum IgG levels due to a reduction in IgG1, IgG3, IgG4 but not IgG2, lower IgA and increased IgM levels compared to controls. The proportion of CD19 + cells did not differ between patients and controls; however the proportion of the naIve IgD + /CD27 − B-cells was increased and the proportion of class-switched memory IgD − /CD27 + B-cells was decreased in the patients. The percentage of CD40 + B-cells did not differ between patients and controls and no aberrations in the CD40-meadiated signal transduction pathway or in CD40-gene polymorphisms were identified. These data provide further evidence that immune disturbances are associated with the pathophysiology of CIN and point out for the first time the implication of the B-cell system. Highlights Patients with CIN display altered serum immunoglobulin levels. Patients with CIN display increased proportion of naIve IgD + /CD27 − B-cells. Patients with CIN display decreased proportion of class-switched memory IgD − /CD27 + B-cells. The CD40-CD40L expression is normal in CIN. The CD40-meadiated signal transduction pathway is normal in CIN.
유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.
원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.
NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.
- 이 논문과 함께 출판된 논문 + 더보기