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Clinical immunology : the official journal of the Clinical Immunology Society v.183, 2017년, pp.82 - 90   SCI SCIE SCOPUS
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Dendritic cells activation is associated with sustained virological response to telaprevir treatment of HCV-infected patients

Sacchi, Alessandra (Cellular Immunology Laboratory, “Lazzaro Spallanzani” National Institute for Infectious Diseases, IRCCS, Rome, Italy ) ; Tumino, Nicola (Cellular Immunology Laboratory, “Lazzaro Spallanzani” National Institute for Infectious Diseases, IRCCS, Rome, Italy ) ; Turchi, Federica (Cellular Immunology Laboratory, “Lazzaro Spallanzani” National Institute for Infectious Diseases, IRCCS, Rome, Italy ) ; Refolo, Giulia (Cellular Biology Laboratory, “Lazzaro Spallanzani” National Institute for Infectious Diseases, IRCCS, Rome, Italy ) ; Fimia, GianMaria (Cellular Biology Laboratory, “Lazzaro Spallanzani” National Institute for Infectious Diseases, IRCCS, Rome, Italy ) ; Ciccosanti, Fabiola (Cellular Biology Laboratory, “Lazzaro Spallanzani” National Institute for Infectious Diseases, IRCCS, Rome, Italy ) ; Montalbano, Marzia (Clinical Division, “Lazzaro Spallanzani” National Institute for Infectious Diseases, IRCCS, Rome, Italy ) ; Lionetti, Raffaella (Clinical Division, “Lazzaro Spallanzani” National Institute for Infectious Diseases, IRCCS, Rome, Italy ) ; Taibi, Chiara (Clinical Division, “Lazzaro Spallanzani” Nation ) ; D'Offizi, Gianpiero ; Casetti, Rita ; Bordoni, Veronica ; Cimini, Eleonora ; Martini, Federico ; Agrati, Chiara ;
  • 초록  

    Abstract First anti-HCV treatments, that include protease inhibitors in conjunction with IFN-α and Ribavirin, increase the sustained virological response (SVR) up to 80% in patients infected with HCV genotype 1. The effects of triple therapies on dendritic cell (DC) compartment have not been investigated. In this study we evaluated the effect of telaprevir-based triple therapy on DC phenotype and function, and their possible association with treatment outcome. HCV+ patients eligible for telaprevir-based therapy were enrolled, and circulating DC frequency, phenotype, and function were evaluated by flow-cytometry. The antiviral activity of plasmacytoid DC was also tested. In SVR patients, myeloid DC frequency transiently decreased, and returned to baseline level when telaprevir was stopped. Moreover, an up-regulation of CD80 and CD86 on mDC was observed in SVR patients as well as an improvement of IFN-α production by plasmacytoid DC, able to inhibit in vitro HCV replication. Highlights Decrease of myeloid dendritic cells from SVR HCV+ patients treated with telaprevir Up-regulation of CD80 and CD86 on mDC from SVR during telaprevir treatment Improvement of IFN-α production by pDC, able to inhibit HCV replication


  • 주제어

    Dendritic cells .   HCV .   Directly acting antivirals .   IFN-α .   T cells.  

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