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Clinical immunology : the official journal of the Clinical Immunology Society v.183, 2017년, pp.121 - 131   SCI SCIE SCOPUS
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IFNA-AS1 regulates CD4+ T cell activation in myasthenia gravis though HLA-DRB1

Luo, Mengchuan (Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ) ; Liu, Xiaofang (Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ) ; Meng, Huanyu (Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ) ; Xu, Liqun (Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ) ; Li, Yi (Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ) ; Li, Zhibin (Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ) ; Liu, Chang (Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ) ; Luo, Yue-Bei (Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ) ; Hu, Bo (Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China ) ; Xue, Yuanyuan (Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008 ) ; Liu, Yu ; Luo, Zhaohui ; Yang, Huan ;
  • 초록  

    Abstract Abnormal CD4 + T cell activation is known to play roles in the pathogenesis of myasthenia gravis (MG). However, little is known about the mechanisms underlying the roles of lncRNAs in regulating CD4 + T cell. In this study, we discovered that the lncRNA IFNG-AS1 is abnormally expressed in MG patients associated with quantitative myasthenia gravis (QMG) and the positive anti-AchR Ab levels patients. IFNG-AS1 influenced Th1/Treg cell proliferation and regulated the expression levels of their transcription factors in an experimental autoimmune myasthenia gravis (EAMG)model. IFNG-AS1 could reduce the expression of HLA-DRB and HLA-DOB and they had a negative correlation in MG. Furthermore IFNG-AS1 influenced the expression levels of CD40L and CD4 + T cells activation in MG patient partly depend on effecting the HLA-DRB1 expression. It suggests that IFNG-AS1 may be involved in CD4 + T cell-mediated immune responses in MG. Highlights IFNG-AS1 decreased Th1, promoted Treg cell proliferation and influenced the expression levels of their transcription factors in EAMG model. IFNG-AS1 reduced the expression levels of CD40L and TF T-bet in CD4 + T cells of MG patient. IFNG-AS1 downregulated CD40L and the transcription factor T-bet partly depend on effecting the HLA-DRB1 expression.


  • 주제어

    Myasthenia gravis .   Long non-coding RNAs (lncRNAs) .   IFNG-AS1 .   CD4+ .   HLA-DOB .   HLA-DRB1.  

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