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Clinical immunology : the official journal of the Clinical Immunology Society v.183, 2017년, pp.158 - 166   SCI SCIE SCOPUS
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Role of S100A9 in the development of neutrophilic inflammation in asthmatics and in a murine model

Lee, Tae-Hyeong (Department of Interdisciplinary Program in Biomedical Science Major, Soonchunhyang Graduate School, Bucheon, Gyeonggi-do 420-767, Republic of Korea ) ; Chang, Hun Soo (Department of Interdisciplinary Program in Biomedical Science Major, Soonchunhyang Graduate School, Bucheon, Gyeonggi-do 420-767, Republic of Korea ) ; Bae, Da-Jeong (Department of Interdisciplinary Program in Biomedical Science Major, Soonchunhyang Graduate School, Bucheon, Gyeonggi-do 420-767, Republic of Korea ) ; Song, Hyun Ji (Department of Interdisciplinary Program in Biomedical Science Major, Soonchunhyang Graduate School, Bucheon, Gyeonggi-do 420-767, Republic of Korea ) ; Kim, Myung-Sin (Department of Internal Medicine, Soonchunhyang University Gumi Hospital, Gumi, Gyeongsangbuk-do 39371, Republic of Korea ) ; Park, Jong Sook (Division of Allergy and Respiratory Disease, Soonchunhyang University Bucheon Hospital, 1174 Jung-dong, Bucheon, Gyeonggi-do 420-767, Republic of Korea ) ; Jun, Ji Ae (Department of Interdisciplinary Program in Biomedical Science Major, Soonchunhyang Graduate School, Bucheon, Gyeonggi-do 42 ) ; Lee, Si Young ; Uh, Soo Taek ; Kim, Soo Hyun ; Park, Choon-Sik ;
  • 초록  

    Abstract S100A9 is an endogenous danger signal that promotes and exacerbates the neutrophilic inflammatory response. To investigate the role of S100A9 in neutrophilic asthma, S100A9 levels were measured in sputum from 101 steroid-naIve asthmatics using an ELISA kit and the levels were significantly correlated with percentages of neutrophils in sputum. Intranasal administration of recombinant S100A9 markedly increased neutrophil numbers at 8h and 24h later with concomitant elevation of IL-1β, IL-17, and IFN-γ levels. Treatment with an anti-S100A9 antibody restored the increased numbers of neutrophils and the increased airway resistance in OVA/CFA mice toward the levels of sham-treated mice. Concomitantly, the S100A9 and neutrophil elastase double positive cells were markedly reduced with attenuation of IL-1β, IL-17, and IFN-γ levels by the treatment with the anti-S100A9 antibody. Our data support a role of S100A9 to initiate and amplify the neutrophilic inflammation in asthma, possibly via inducing IL-1β, IL-17 and IFN-γ. Highlight S100A9 is an endogenous danger signal that promotes and exacerbates the neutrophilic inflammatory response. Our data support a role of S100A9 to initiate and amplify the neutrophilic inflammation via inducing IL-1β, IL-17 and IFN-γ. Modulation of S100A9 in the airway may be a therapeutic strategy to control neutrophilic inflammation in asthma.


  • 주제어

    Calgranulin B .   S100A9 .   Asthma .   IL-1β .   IL-17 .   IFN-γ.  

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