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Clinical immunology : the official journal of the Clinical Immunology Society v.183, 2017년, pp.174 - 180   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Estrogen decreases tight junction protein ZO-1 expression in human primary gut tissues

Zhou, Zejun (Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA ) ; Zhang, Lumin (Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA ) ; Ding, Miao (Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA ) ; Luo, Zhenwu (Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA ) ; Yuan, Shao (The Biorepository & Tissue Analysis Shared Resource, Hollings Cancer Center, Medical University of South Carolina, SC 29425, USA ) ; Bansal, Meena B. (Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA ) ; Gilkeson, Gary (Division of Rheumatology, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA ) ; Lang, Ren (Department of Hepatobiliary Surgery, Beijing Chaoyang Hospital, Capital Medical University, Chaoyang Qu, Beijing 10020, China ) ; Jiang, Wei (Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, SC 29425, USA ) ;
  • 초록  

    Abstract Females have a higher prevalence of most autoimmune diseases; however, the mechanism is unknown. In this study, we examined the expression of tight junction protein zonula occludens 1 (ZO-1) and estrogen receptor (ER)-α/β in human primary gut tissues by immunohistochemistry, immunofluorescence and qPCR. The expression of ZO-1 and ER-β but not ER-α was present in both male and female gut tissues. There was no sex difference in ER-β expression, but ZO-1 expression was decreased in females compared to males. In vitro , estrogen treatment decreased ZO-1 mRNA and protein expression, ZO-1 promoter activity, IL-6 production, and NF-κB activation in human primary gut tissues or the Caco-2 cells, but increased the ER-β expression in Caco-2 cells. Consistently, plasma IL-6 levels in females were reduced relative to males in vivo . Our finding indicates that estrogen may play a role in gut tight junction expression and permeability.


  • 주제어

    Sex differences .   estrogen .   ZO-1 .   gut tissues.  

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