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Clinical immunology : the official journal of the Clinical Immunology Society v.183, 2017년, pp.191 - 197   SCI SCIE SCOPUS
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HLA class Ia and Ib molecules and FOXP3+ TILs in relation to the prognosis of malignant melanoma patients

Melsted, Wenna Nascimento (Centre for Immune Regulation and Reproductive Immunology (CIRRI), Department of Clinical Biochemistry, Zealand University Hospital, DK-4000 Roskilde, Denmark ) ; Johansen, Lasse Lindholm (Centre for Immune Regulation and Reproductive Immunology (CIRRI), Department of Clinical Biochemistry, Zealand University Hospital, DK-4000 Roskilde, Denmark ) ; Lock-Andersen, Jørgen (Department of Plastic Surgery, Zealand University Hospital, Roskilde, Denmark ) ; Behrendt, Nille (Department of Pathology, Zealand University Hospital, Denmark ) ; Eriksen, Jens Ole (Department of Pathology, Zealand University Hospital, Denmark ) ; Bzorek, Michael (Department of Pathology, Zealand University Hospital, Denmark ) ; Scheike, Thomas (Department of Biostatistics, University of Copenhagen, Denmark ) ; Hviid, Thomas Vauvert F. (Centre for Immune Regulation and Reproductive Immunology (CIRRI), Department of Clinical Biochemistry, Zealand University Hospital, DK-4000 Roskilde, Denmark ) ;
  • 초록  

    Abstract HLA class Ia (HLA-ABC) and HLA class Ib (HLA-E, -F and -G) molecules and FOXP3+ tumor-infiltrating lymphocytes (TILs) are often reported as relevant factors of tumor immune regulation. We investigated their expression as prognostic factors in 200 patients with primary cutaneous melanoma (PCM). In our cohort, patients with tumors showing upregulation of HLA-ABC molecules had significantly thicker tumors (32% vs 7%, P P = 0.007) and frequent nodular melanomas (20% vs 4%, P = 0.001). Additionally, high expression of HLA-G in the tumor was a sign of bad prognosis for the patients, being associated with thick tumors (30% vs 12%, P = 0.017), ulceration (24% vs 5%, P P = 0.015). HLA-E, HLA-F and FOXP3+ TILs were not indicative of the prognosis in PCM. High HLA-ABC and HLA-G were associated with tumor aggressiveness and could be relevant predictive markers for effective immunotherapy of melanoma tumors. Highlights Melanoma tumors are more aggressive when expressing high levels of HLA-ABC and HLA-G. HLA-G expression is correlated with a high number of FOXP3+ lymphocytes in the tumor. High HLA-ABC expression is associated with bad prognostic factors.


  • 주제어

    Malignant melanoma .   HLA .   FOXP3+ .   Regulatory T cells .   Prognosis.  

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