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Clinical immunology : the official journal of the Clinical Immunology Society v.183, 2017년, pp.225 - 232   SCI SCIE SCOPUS
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Systemic manifestations of primary SjOgren's syndrome in the NOD.B10Sn-H2 b /J mouse model

Kiripolsky, Jeremy (Department of Oral Biology, School of Dental Medicine, University of Buffalo, The State University of New York, Buffalo, NY 14214, USA ) ; Shen, Long (Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen University, Xiamen 361003, China ) ; Liang, Yichen (Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA ) ; Li, Alisa (Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA ) ; Suresh, Lakshmanan (Autoimmune Division, Trinity Biotech, 60 Pineview Drive, Buffalo, NY 14228, USA ) ; Lian, Yun (Microarray Core Facility, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA ) ; Li, Quan-Zhen (Microarray Core Facility, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390, USA ) ; Gaile, Daniel P. (Department of Biostatistics, School of Public Health and Health Professions, University of Buffalo, The State University of New York, 3435 Main Street, 718 Kimball Tower, Buffalo, NY 14214, USA ) ; Kramer, Jill M. (Department of Oral Biology, Sch ) ;
  • 초록  

    Abstract Animal models that recapitulate human disease are crucial for the study of SjOgren's Syndrome (SS). While several SS mouse models exist, there are few primary SS (pSS) models that mimic systemic disease manifestations seen in humans. Similar to pSS patients, NOD.B10Sn- H2 b /J (NOD.B10) mice develop exocrine gland disease and anti-nuclear autoantibodies. However, the disease kinetics and spectrum of extra-glandular disease remain poorly characterized in this model. Our objective was to characterize local and systemic SS manifestations in depth in NOD.B10 female mice at early and late disease time points. To this end, sera, exocrine tissue, lung, and kidney were analyzed. NOD.B10 mice have robust lymphocytic infiltration of salivary and lacrimal tissue. In addition, they exhibit significant renal and pulmonary inflammation. We identified numerous autoantibodies, including those directed against salivary proteins. In conclusion, the NOD.B10 model recapitulates both local and systemic pSS disease and represents an excellent model for translational studies. Highlights NOD.B10 mice represent an excellent model for primary SjOgren's syndrome (pSS). NOD.B10 females exhibit sialadenitis and dacryoadenitis and lose salivary flow. NOD.B10 mice also show extra-glandular manifestations of pSS. Similar to some pSS patients, NOD.B10 females show pulmonary and renal inflammation. Novel SS autoantibodies are elevated in sera from NOD.B10 mice.


  • 주제어

    Sjögren's syndrome .   Autoantibodies .   Extra-glandular disease .   NOD.   B10.  

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