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Clinical immunology : the official journal of the Clinical Immunology Society v.183, 2017년, pp.285 - 292   SCI SCIE SCOPUS
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Asthmatic farm children show increased CD3+ CD8low T-cells compared to non-asthmatic farm children

Twardziok, Monika (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany ) ; Schröder, Paul C. (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany ) ; Krusche, Johanna (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany ) ; Casaca, Vera I. (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany ) ; Illi, Sabina (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany ) ; Böck, Andreas (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany ) ; Loss, Georg J. (Dr. von Hauner Children's Hospital, Ludwig Maximilians University Munich, Munich, Germany ) ; Kabesch, Michael (Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany ) ; Toncheva, Antoaneta A. (Department of Pediatric Pneumology and Allergy, University Children's Hospital Regensburg (KUNO), Regensburg, Germany ) ; Roduit, Caroline (Zurich University Children's Hospital, Zurich, Switzerland ) ; Depner, Martin (Dr. von Hauner Children's Hospital, Ludwig Maximilians ) ; Genuneit, Jon ; Renz, Harald ; Roponen, Marjut ; Weber, Juliane ; Braun-Fahrländer, Charlotte ; Riedler, Josef ; Lauener, Roger ; Vuitton, Dominique Angèle ; Dalphin, Jean-Charles ; Pekkanen, Juha ; von Mutius, Erika ; Schaub, Bianca ; Hyvärinen, Anne ; Karvonen, Anne M. ; Kirjavainen, Pirkka V. ; Remes, Sami ; Kaulek, Vincent ; Dalphin, Marie-Laure ; Ege, Markus ; Pfefferle, Petra I. ; Doekes, Gert ;
  • 초록  

    Highlights Asthmatic farm children exhibit more CD3 + CD8 low T-cells compared to non-asthmatic farm children. IFN-γ secretion is decreased in asthmatic compared to non-asthmatic farm-exposed children Asthmatic farm children with asthma risk alleles have more CD3 + CD8 low T-cells than non-asthmatic children with risk alleles. The amount of CD8 low T-cells indicates a specific farm-dependent mechanism associated with childhood asthma.


    Abstract Several studies report an important role of CD8 + cytotoxic T-cells in atopy. Farm children show protection against atopy development, partly explained by CD4 + T-cell subtypes. Additional effects of CD8 + T-cells are unknown being investigated in this study within the PASTURE/EFRAIM birth cohort in PBMCs from farming and non-farming 6-year-old ( N = 76) German children. CD3 + CD8 + CD25 + T-cells were analyzed by flow cytometry. Genotyping of 17q21 locus-SNPs associated with childhood asthma was performed. No differences in CD8 + T-cell subsets were seen between farmers and non-farmers regardless of asthma. Among farm children, asthmatics displayed increased CD3 + CD8 low (CD25 + ) T-cells compared to non-asthmatics. Asthmatic farm children exhibited a lower PI-induced stimulatory capacity of CD3 + CD8 low (CD25 + ) cells and a lower IFN-γ secretion than non-asthmatic farm children. Among farm children with GSDMB and ORMDL3 risk alleles, asthmatics displayed higher CD3 + CD8 low cells than non-asthmatics. Our data indicates a specific role of CD8 low T-cells in asthmatic farm children.


  • 주제어

    CD8+ .   CD8low .   Childhood .   Farm-exposure.  

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