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Clinical immunology : the official journal of the Clinical Immunology Society v.183, 2017년, pp.293 - 299   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Increased innate type 2 immune response in house dust mite-allergic patients with allergic rhinitis

Zhong, Hua (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) ; Fan, Xing-Liang (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) ; Yu, Qiu-Ning (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) ; Qin, Zi-Li (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) ; Chen, Dong (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) ; Xu, Rui (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) ; Chen, De-Hua (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) ; Lin, Zhi-Bin (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) ; Wen, Weiping (Otorhinolaryngology Hospital, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China ) ; Fu, Qing-Ling (O ) ;
  • 초록  

    Abstract Group 2 innate lymphoid cells (ILC2s) are essential in initiating and driving allergic immune responses. However, there were inconsistent findings of the ILC2 levels in allergic rhinitis (AR) patients. This study investigated the ILC2 levels in the peripheral blood of house dust mite (HDM)-sensitized AR patients and their ability to secrete type 2 cytokines. The levels of ILC2s with phenotypic ILC2 characteristics were increased in the HDM-AR patients. The AR patients' symptom score and IL-13 levels were positively associated with the ILC2s in HDM-AR patients. The epithelial cytokine stimulation induced dramatic production of IL-5 and IL-13 in PBMCs of AR patients. We successfully sorted ILC2s from AR patients and identified their ability of type 2 cytokines production. The number of ILC2s increased in the HDM-AR patients and ILC2s produced the amount of T H 2 cytokines in the presence of epithelial cytokines, which suggested the important role of ILC2 in AR patients. Highlights ILC2s was elevated in HDM-sensitized AR patients. ILC2s from AR patients produced more T H 2 cytokines. ILC2s may be involved in the HDM-AR, which could be a potential therapeutic target for AR.


  • 주제어

    Allergic rhinitis .   Innate immunity .   Group 2 innate lymphoid cells .   TH2 cytokines.  

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