본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Clinical immunology : the official journal of the Clinical Immunology Society v.183, 2017년, pp.304 - 315   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

Depressed serum IgM levels in SLE are restricted to defined subgroups

Grönwall, Caroline (Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden ) ; Hardt, Uta (Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden ) ; Gustafsson, Johanna T. (Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden ) ; Elvin, Kerstin (Department of Clinical Immunology and Transfusion Medicine, Unit of Clinical Immunology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden ) ; Jensen-Urstad, Kerstin (Department of Clinical Physiology, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden ) ; Kvarnström, Marika (Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden ) ; Grosso, Giorgia (Department of Medicine, Rheumatology Unit, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden ) ; Rönnelid, Johan (Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden ) ; Padykov, Leonid (Department of Medicine, Rheumatology Unit, Karolinska Insti ) ; Gunnarsson, Iva ; Silverman, Gregg J. ; Svenungsson, Elisabet ;
  • 초록  

    Abstract Natural IgM autoantibodies have been proposed to convey protection from autoimmune pathogenesis. Herein, we investigated the IgM responses in 396 systemic lupus erythematosus (SLE) patients, divided into subgroups based on distinct autoantibody profiles. Depressed IgM levels were more common in SLE than in matched population controls. Strikingly, an autoreactivity profile defined by IgG anti-Ro/La was associated with reduced levels of specific natural IgM targeting phosphorylcholine (PC) antigens and malondialdehyde (MDA) modified-protein, as well as total IgM, while no differences were detected in SLE patients with an autoreactivity profile defined by anti-cardiolipin/β 2 glycoprotein-I. We also observed an association of reduced IgM levels with the HLA-DRB1*03 allelic variant among SLE patients and controls. Associations of low IgM anti-PC with cardiovascular disease were primarily found in patients without antiphospholipid antibodies. These studies further highlight the clinical relevance of depressed IgM. Our results suggest that low IgM levels in SLE patients reflect immunological and genetic differences between SLE subgroups. Highlights Low IgM levels are more common in SLE patients than in controls. Patients with anti-Ro/La autoimmunity often have strikingly decreased IgM levels. Low IgM was seen for specific IgM anti-PC, anti-MDA, anti-CWPS, as well as total IgM. Low natural IgM may be associated to HLA-DRB1*03 in both SLE and controls.


  • 주제어

    SLE .   Natural IgM .   Sjögren's syndrome .   Antiphospholipid syndrome .   IgM anti-PC .   IgM anti-MDA .   IgM anti-CWPS .   SS .   APS .   Autoantibodies.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.
유료다운로드

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기