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Clinical immunology : the official journal of the Clinical Immunology Society v.183, 2017년, pp.336 - 343   SCI SCIE SCOPUS
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Circulating B cells in type 1 diabetics exhibit fewer maturation-associated phenotypes

Hanley, Patrick (Division of Endocrinology and Diabetes, The Children's Hospital of Philadelphia, Philadelphia, PA, USA ) ; Sutter, Jennifer A. (Division of Endocrinology and Diabetes, East Carolina University Pediatrics Specialty Clinic, Greenville, NC, USA ) ; Goodman, Noah G. (Division of Hematology/Oncology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA ) ; Du, Yangzhu (Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA ) ; Sekiguchi, Debora R. (Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada ) ; Meng, Wenzhao (Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA ) ; Rickels, Michael R. (Division of Endocrinology, Diabetes and Metabolism, Hospital of the University of Pennsylvania, Philadelphia, PA, USA ) ; Naji, Ali (Department of Surgery, Hospital of the University of Pennsylvania, Philadelphia, PA, USA ) ; Luning Prak, Eline T. (Department of Pathology and Laboratory Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphi ) ;
  • 초록  

    Abstract Although autoantibodies have been used for decades as diagnostic and prognostic markers in type 1 diabetes (T1D), further analysis of developmental abnormalities in B cells could reveal tolerance checkpoint defects that could improve individualized therapy. To evaluate B cell developmental progression in T1D, immunophenotyping was used to classify circulating B cells into transitional, mature naIve, mature activated, and resting memory subsets. Then each subset was analyzed for the expression of additional maturation-associated markers. While the frequencies of B cell subsets did not differ significantly between patients and controls, some T1D subjects exhibited reduced proportions of B cells that expressed transmembrane activator and CAML interactor (TACI) and Fas receptor (FasR). Furthermore, some T1D subjects had B cell subsets with lower frequencies of class switching. These results suggest circulating B cells exhibit variable maturation phenotypes in T1D. These phenotypic variations may correlate with differences in B cell selection in individual T1D patients.


  • 주제어

    B lymphocytes .   Type 1 diabetes .   TACI .   FasR.  

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