본문 바로가기
HOME> 논문 > 논문 검색상세

논문 상세정보

Experimental and molecular pathology v.103 no.2, 2017년, pp.181 - 190   SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

T cell-mediated antitumor immune response eliminates skin tumors induced by mouse papillomavirus, MmuPV1

Joh, Joongho (James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA ) ; Chilton, Paula M. (Christine M. Kleinert Institute for Hand & Microsurgery, 225 Abraham Flexner Way, Suite 850, Louisville, KY, USA ) ; Wilcher, Sarah A. (Research Resources Center, 530 South Jackson Street, Louisville, KY, USA ) ; Zahin, Maryam (James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA ) ; Park, Jino (James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA ) ; Proctor, Mary L. (Research Resources Center, 530 South Jackson Street, Louisville, KY, USA ) ; Ghim, Shin-je (James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA ) ; Jenson, Alfred B. (James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA ) ;
  • 초록  

    Abstract Previous studies of naturally occurring mouse papillomavirus (PV) MmuPV1-induced tumors in B6.Cg- Foxn1 nu/nu mice suggest that T cell deficiency is necessary and sufficient for the development of such tumors. To confirm this, MmuPV1-induced tumors were transplanted from T cell-deficient mice into immunocompetent congenic mice. Consequently, the tumors regressed and eventually disappeared. The elimination of MmuPV1-infected skin/tumors in immunocompetent mice was consistent with the induction of antitumor T cell immunity. This was confirmed by adoptive cell experiments using hyperimmune splenocytes collected from graft-recipient mice. In the present study, such splenocytes were injected into T cell-deficient mice infected with MmuPV1, and they eliminated both early-stage and fully formed tumors. We clearly show that anti-tumor T cell immunity activated during tumor regression in immunocompetent mice effectively eliminates tumors developing in T cell-deficient congenic mice. The results corroborate the notion that PV-induced tumors are strongly linked to the immune status of the host, and that PV antigens are major anti-tumor antigens. Successful anti-PV T cell responses should, therefore, lead to effective anti-tumor immune therapy in human PV-infected patients.


  • 주제어

    Mouse papillomavirus .   T cell-mediated anticancer immunity .   Tumor graft .   Cytotoxic effect on tumor .   Human papillomavirus-associated disease.  

 활용도 분석

  • 상세보기

    amChart 영역
  • 원문보기

    amChart 영역

원문보기

무료다운로드
  • 원문이 없습니다.

유료 다운로드의 경우 해당 사이트의 정책에 따라 신규 회원가입, 로그인, 유료 구매 등이 필요할 수 있습니다. 해당 사이트에서 발생하는 귀하의 모든 정보활동은 NDSL의 서비스 정책과 무관합니다.

원문복사신청을 하시면, 일부 해외 인쇄학술지의 경우 외국학술지지원센터(FRIC)에서
무료 원문복사 서비스를 제공합니다.

NDSL에서는 해당 원문을 복사서비스하고 있습니다. 위의 원문복사신청 또는 장바구니 담기를 통하여 원문복사서비스 이용이 가능합니다.

이 논문과 함께 출판된 논문 + 더보기