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Molecular and cellular neurosciences v.84, 2017년, pp.36 - 47   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

It takes a village to raise a branch: Cellular mechanisms of the initiation of axon collateral branches

Armijo-Weingart, Lorena (Corresponding author. ); Gallo, Gianluca ( );
  • 초록  

    Abstract The formation of axon collateral branches from the pre-existing shafts of axons is an important aspect of neurodevelopment and the response of the nervous system to injury. This article provides an overview of the role of the cytoskeleton and signaling mechanisms in the formation of axon collateral branches. Both the actin filament and microtubule components of the cytoskeleton are required for the formation of axon branches. Recent work has begun to shed light on how these two elements of the cytoskeleton are integrated by proteins that functionally or physically link the cytoskeleton. While a number of signaling pathways have been determined as having a role in the formation of axon branches, the complexity of the downstream mechanisms and links to specific signaling pathways remain to be fully determined. The regulation of intra-axonal protein synthesis and organelle function are also emerging as components of signal-induced axon branching. Although much has been learned in the last couple of decades about the mechanistic basis of axon branching we can look forward to continue elucidating this complex biological phenomenon with the aim of understanding how multiple signaling pathways, cytoskeletal regulators and organelles are coordinated locally along the axon to give rise to a branch. Highlights Branching requires coordination of the cytoskeleton. Coordination of the cytoskeleton is mediated by actin-microtubule binding proteins. Mitochondria have a pivotal role in determining sites of branching. Mitochondria function regulates the axonal actin filament cytoskeleton. Intra-axonal protein synthesis is required for NGF-induced branching.


  • 주제어

    Interstitial branch .   Axon sprouting .   Neuronal morphogenesis .   Neurite .   Filopodia.  

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