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Molecular and cellular neurosciences v.84, 2017년, pp.85 - 92   SCI SCIE SCOPUS
본 등재정보는 저널의 등재정보를 참고하여 보여주는 베타서비스로 정확한 논문의 등재여부는 등재기관에 확인하시기 바랍니다.

The role of drebrin in dendritic spines

Koganezawa, Noriko (Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan ); Hanamura, Kenji (Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan ); Sekino, Yuko (Division of Pharmacology, National Institute of Health Sciences, Tokyo 158-8501, Japan ); Shirao, Tomoaki (Department of Neurobiology and Behavior, Gunma University Graduate School of Medicine, Maebashi 371-8511, Japan );
  • 초록  

    Abstract Dendritic spines form typical excitatory synapses in the brain and their shapes vary depending on synaptic inputs. It has been suggested that the morphological changes of dendritic spines play an important role in synaptic plasticity. Dendritic spines contain a high concentration of actin, which has a central role in supporting cell motility, and polymerization of actin filaments (F-actin) is most likely involved in spine shape changes. Drebrin is an actin-binding protein that forms stable F-actin and is highly accumulated within dendritic spines. Drebrin has two isoforms, embryonic-type drebrin E and adult-type drebrin A, that change during development from E to A. Inhibition of drebrin A expression results in a delay of synapse formation and inhibition of postsynaptic protein accumulation, suggesting that drebrin A has an important role in spine maturation. In mature synapses, glutamate stimulation induces rapid spine-head enlargement during long-term potentiation (LTP) formation. LTP stimulation induces Ca 2+ entry through N -methyl- D -aspartate (NMDA) receptors, which causes drebrin exodus from dendritic spines. Once drebrin exits from dendritic spine heads, the dynamic actin pool increases in spine heads to facilitate F-actin polymerization. To maintain enlarged spine heads, drebrin-decorated F-actin is thought to reform within the spine heads. Thus, drebrin plays a pivotal role in spine plasticity through regulation of F-actin. Highlights In dendritic spines, there are distinct dynamic and stable pools of F-actin. Drebrin, an actin-binding protein, forms stable F-actin. Drebrin-decorated F-actin may form a platform for postsynaptic protein assembly. Exodus of drebrin-decorated F-actin occurs during LTP initiation. Deficits in LTP formation in drebrin-A knockout mice lead to fear memory impairment.


  • 주제어

    Stable actin filament .   Dynamic actin filament .   Plasticity .   Cytoskeleton.  

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