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Molecular and cellular neurosciences v.84, 2017년, pp.112 - 118   SCI SCIE SCOPUS
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A role for tropomyosins in activity-dependent bulk endocytosis?

Gormal, Rachel (The University of Queensland, Queensland Brain Institute, Clem Jones Centre for Ageing Dementia Research, Brisbane, Queensland 4072, Australia ) ; Valmas, Nicholas (The University of Queensland, Queensland Brain Institute, Brisbane, Queensland 4072, Australia ) ; Fath, Thomas (School of Medical Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia ) ; Meunier, Frederic (The University of Queensland, Queensland Brain Institute, Clem Jones Centre for Ageing Dementia Research, Brisbane, Queensland 4072, Australia ) ;
  • 초록  

    Abstract Bulk endocytosis allows stimulated neurons to take up a large portion of the presynaptic plasma membrane in order to regenerate synaptic vesicle pools. Actin, one of the most abundant proteins in eukaryotic cells, plays an important role in this process, but a detailed mechanistic understanding of the involvement of the cortical actin network is still lacking, in part due to the relatively small size of nerve terminals and the limitation of optical microscopy. We recently discovered that neurosecretory cells display a similar, albeit much larger, form of bulk endocytosis in response to secretagogue stimulation. This allowed us to identify a novel highly dynamic role for the acto-myosin II cortex in generating constricting rings that precede the fission of nascent bulk endosomes. In this review we focus on the mechanism underpinning this dramatic switch in the organization and function of the cortical actin network. We provide additional experimental data that suggest a role of tropomyosin Tpm3.1 and Tpm4.2 in this process, together with an emerging model of how actin controls bulk endocytosis. Highlights Bulk endocytosis is activated in neurons and neurosecretory cells following strong stimulus. It requires the activation of several steps requiring calcium leading to the recruitment of adaptor proteins. We show that tropomyosin is recruited to bulk endosomes and may therefore be involved in fission of nascent endosomes. A scheme highlighting the role of key component of bulk endocytosis is proposed.


  • 주제어

    Cortical actin network .   Myosin II .   Tropomyosin .   Bulk endocytosis .   Exocytosis .   Cytoskeleton.  

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