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Molecular and cellular neurosciences v.84, 2017년, pp.132 - 141   SCI SCIE SCOPUS
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Systemic and network functions of the microtubule-associated protein tau: Implications for tau-based therapies

Bakota, Lidia (Corresponding author at: Department of Neurobiology, University of Osnabrück, Barbarastraße 11, D-49076 Osnabrück, Germany ); Ussif, Abdala ( ); Jeserich, Gunnar ( ); Brandt, Roland ( );
  • 초록  

    Abstract Tau is a microtubule-associated neuronal protein, whose primary role was long thought to regulate axonal microtubule assembly. Tau is subject to many posttranslational modifications and can aggregate into neurofibrillary tangles, which are considered to be a hallmark of several neurodegenerative diseases collectively called “tauopathies”. The most common tauopathy is Alzheimer's disease, where tau pathology correlates with sites of neurodegeneration. Tau belongs to the class of intrinsically disordered proteins, which are known to interact with many partners and are considered to be involved in various signaling, regulation and recognition processes. Thus more recent evidence indicates that tau functionally interacts with many proteins and different cellular structures, which may have an important physiological role and may be involved in neurodegenerative processes. Furthermore, tau can be released from neurons and exert functional effects on other cells. This review article weighs the evidence that tau has subtle but important systemic effects on neuronal network function by maintaining physiological neuronal transmission and synaptic plasticity, which are possibly independent from tau's microtubule modulating activities. Implications for tau-based therapeutic approaches are discussed. Highlights Tau protein is a promiscuous binder involved in signaling, regulation and recognition processes. Tau is involved in neurodegenerative events triggered by various insults. Tau has systemic effects on neuronal network function. Side-effects by reducing tau levels need to be considered in tau-based therapies.


  • 주제어

    Alzheimer's disease .   Tau .   Microtubule-associated protein .   Tauopathy .   Neuronal network.  

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